Evidence map›Paper›PMID 39379984›Full record

ArticleParticle and fibre toxicology2024

A pilot study of the cardiopulmonary effects in healthy volunteers after exposure to high levels of PM

David G Luglio, Kayla Rae Farrell, Terry Gordon

Abstract read
In one paragraph

Article in Particle and fibre toxicology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

David G LuglioDepartment of Environmental Health Sciences, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA.
Kayla Rae FarrellDivision of Environmental Medicine, Grossman School of Medicine, New York University, New York, NY, USA.
Terry GordonDivision of Environmental Medicine, Grossman School of Medicine, New York University, New York, NY, USA. terry.gordon@nyulangone.org.

Funding

Pilot Projects/Mt. SinaiT42OH008422 · OH · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI MEYER, JOHN D · 2005 to 2025
$28.6M
RESEARCH IN ENVIRONMENTAL HEALTH SCIENCES (CENTER GRANT)P30ES000260 · NIEHS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ZELIKOFF, JUDITH TERRY · 1985 to 2020
$26.1M
TRAINING PROGRAM IN ENVIRONMENTAL TOXICOLOGYT32ES007324 · NIEHS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CUDDAPAH, SURESH · 1999 to 2025
$5.8M
NIEHS NIH HHS ES000260NIEHS NIH HHS P30 ES000260NIEHS NIH HHS T32 ES007324NIH HHS ES007324NIOSH CDC HHS T42 OH008422
6 · The paper itself

Abstract

backgroundSubway systems are becoming increasingly common worldwide transporting large populations in major cities. PM

methodsHealthy volunteers in New York City were exposed to a 2-h visit on the 9th Street Station platform on the Port Authority Trans-Hudson train system. Blood pressure, heart rate variability (HRV), spirometry, and forced impulse oscillometry were measured, and urine, blood spot, and nasal swab biosamples were collected for cytokine analysis at the end of the 2-h exposure period. These endpoints were compared against individual control measurements collected after 2-h in a "clean" control space. In addition to paired comparisons, mixed effects models with subject as a random effect were employed to investigate the effect of the PM

resultsMean PM

conclusionsAcute exposures to PM on a subway platform do not cause measurable cardiopulmonary effects apart from reductions in HRV and increases in symptoms in healthy volunteers. These findings match other studies that found little to no changes in lung function and blood pressure after exposure in underground subway stations. Future work should still target potentially more vulnerable populations, such as individuals with asthma or those who spend increased time underground on the subway such as transit workers.

Indexed as

Blood PressureCytokinesHealthy VolunteersHeart RateParticulate MatterAdultAir PollutantsFemaleHumansInhalation ExposureLungMaleMiddle AgedNew York CityParticle SizePilot ProjectsAir PollutantsCytokinesParticulate MatterAir pollutionBlood pressureCardiopulmonaryExposureHeart rate variabilityMetalsOscillometryPM2.5SpirometrySubwayUrban environment

Identifiers

PMID39379984
PMCPMC11460011

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.