ArticleBMC public health2024
Associations of cardiometabolic index with diabetic statuses and insulin resistance: the mediating role of inflammation-related indicators.
Article in BMC public health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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39 citing papers in PubMed.
- Association of Waist Circumference and Body Composition Indices with Insulin Resistance in Prepubertal Children with Obesity.Metabolites · 2026Article
- Association between the cardiometabolic index and intrinsic capacity and its domains in older adults: a study based on CHARLS data.BMC geriatrics · 2026Article
- Composite C-reactive protein-triglyceride-glucose-adiposity indices and incident cardiovascular disease in the CHARLS cohort: a prospective cohort study.Cardiovascular diabetology · 2026Article
- Association between cardiometabolic index and high-sensitivity C-reactive protein: A cross-sectional study from National Health and Nutrition Examination Survey 2015 to 2018.The Journal of international medical research · 2026Article
- Association between cardiometabolic index and major adverse cardio-cerebral events and all-cause mortality in patients with degenerative aortic stenosis: a retrospective cohort study.Journal of thoracic disease · 2026Article
- E-selectin, but not CRP, partially mediates the association between metabolic indices and insulin resistance in older adults: a mediation analysis.Asian biomedicine : research, reviews and news · 2026Article
- Glycaemic Status Modifies the Association Between Cardiometabolic Index and Cardio-Kidney Outcomes: A Multi-Cohort Analysis.Diabetes/metabolism research and reviews · 2026Article
- Predictive performance of cardiometabolic indices for prediabetes progression to diabetes and reversion to normoglycemia in adults: a cohort study.Frontiers in nutrition · 2026Article
- Association between cardiometabolic index change patterns and incident cardiovascular disease in middle-aged and older adults.Frontiers in cardiovascular medicine · 2026Article
- Association Between Cardiometabolic Index and Diabetic Retinopathy in Patients with Type 2 Diabetes Mellitus.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
- The modified cardiometabolic index as a simple screening tool for cardiovascular disease risk: a cohort study.Scientific reports · 2025Article
- Higher cardiometabolic index elevates the risk of hyperuricemia in the elderly: findings from the China health and retirement longitudinal study.Annals of medicine · 2025Article
- Association between erectile dysfunction and relative fat mass in adult men in the United States.Translational andrology and urology · 2025Article
- Dietary Strawberries Improve Serum Antioxidant Profiles in Adults with Prediabetes: A 28-Week Randomized Controlled Crossover Trial.Antioxidants (Basel, Switzerland) · 2025Article
- Association of lipid accumulation product with the prevalence and incidence of sarcopenia: a nationwide study in Chinese.Nutrition & metabolism · 2025Article
- Prognostic nutritional index, sarcopenia, and risk of mortality: a national population-based study.Nutrition & metabolism · 2025Article
- Article
- Association between cardiometabolic index and sarcopenia: 2011-2018 National Health and Nutrition Examination survey (NHANES).Journal of clinical & translational endocrinology · 2025Article
- Association between prognostic nutritional index and risk of moderate-to-severe basic activities of daily living dependence two years after hip fracture surgery in older adults.BMC geriatrics · 2025Article
- Associations between cardiometabolic indices and heart disease among elderly and middle-aged Chinese individuals: a retrospective longitudinal study.Scientific reports · 2025Observational
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12 authors.
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Abstract
backgroundThis study aimed to analyze the associations of cardiometabolic index (CMI) with diabetic statuses and insulin resistance (IR) using data from the National Health and Nutrition Examination Survey (NHANES) and examined the potential mediating role of inflammation in these correlations.
methodsThis study enrolled 9477 participants across four NHANES cycles from 2011 to 2018. The primary outcomes of the study included the risk of having prediabetes, diabetes and the level of the homeostasis model assessment of IR (HOMA-IR). Other outcomes including the levels of fasting blood glucose (FBG), hemoglobin A1c (HbA1c), oral glucose tolerance test (OGTT) results, fasting insulin, the risk of oral hypoglycemic medicine use, insulin use, and retinopathy were also collected and analyzed. Logistic regression model, subgroup analysis, restricted cubic spine (RCS), and Pearson correlation coefficients were conducted to assess the associations of CMI with diabetic statuses and IR. The mediating role of inflammation was evaluated to investigate the potential mechanism of the associations between CMI and diabetic statuses.
resultsAmong included participants, the CMI levels in normal participants, prediabetes and diabetes in this study were 0.48, 0.73 and 1.07. After multivariable adjustment, CMI was positively associated with the risk of prediabetes (OR = 1.49, 95% CI = 1.24-1.79), diabetes (OR = 2.14, 95% CI = 1.82-2.50) and the level of HOMA-IR (β = 2.57, 95% CI = 2.14-3.01). Besides, an increased CMI was correlated with higher levels of FBG, HBA1c, OGTT results and fasting insulin as well as the greater risk of oral hypoglycemic medicine use and insulin use. The RCS showed an inverted L-shaped association of CMI with prediabetes and diabetes (P for non-linearity < 0.001). According to Pearson correlation coefficients, higher CMI was linked to higher rises in HOMA-IR (r = 0.224, P < 0.001). Inflammation-related indicators including leukocyte and neutrophil demonstrated significant mediating effects in the associations of CMI with prediabetes (15.5%, 9.8%), diabetes (5.1%, 6.0%) and HOMA-IR (3.3%, 2.6%).
conclusionCMI was positively associated with the risk of worse diabetic statuses and higher level of IR while the associations may be partially mediated by inflammation-related indicators, suggesting that CMI could be a promising indicator for the prediction of severe diabetes and IR.
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