Evidence map›Paper›PMID 39379708›Full record

ReviewEuropean radiology2025

Advanced breast diffusion-weighted imaging: what are the next steps? A proposal from the EUSOBI International Breast Diffusion-weighted Imaging working group.

Maya Honda, Eric E Sigmund, Denis Le Bihan, Katja Pinker, Paola Clauser, Dimitrios Karampinos, Savannah C Partridge, Eva Fallenberg, Laura Martincich, Pascal Baltzer and 4 more

Abstract readReview
In one paragraph

Review in European radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Quantitative MR Imaging of the Breast.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2025
    Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Maya HondaDepartment of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Eric E SigmundDepartment of Radiology, NYU Langone Health, 6, 60 1st Avenue, New York, NY, 10016, USA.
Denis Le BihanNeuroSpin/Joliot, CEA-Saclay Center, Paris-Saclay University, Gif-sur-Yvette, France.
Katja PinkerDepartment of Radiology, Breast Imaging Division, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Paola ClauserDepartment of Biomedical Imaging and Image-guided Therapy, Division of Molecular and Structural Preclinical Imaging, Medical University of Vienna/Vienna General Hospital, Wien, Austria.
Dimitrios KarampinosDepartment of Diagnostic and Interventional Radiology, Technical University of Munich, Munich, Germany.
Savannah C PartridgeDepartment of Radiology, University of Washington School of Medicine, Seattle, WA, USA.
Eva FallenbergDepartment of Diagnostic and Interventional Radiology, Technical University of Munich, Munich, Germany.
Laura MartincichUnit of Radiodiagnostics, Ospedale Cardinal G. Massaia -ASL AT, Via Conte Verde 125, 14100, Asti, Italy.
Pascal BaltzerDepartment of Diagnostic and Interventional Radiology, Technical University of Munich, Munich, Germany.
Ritse M MannDepartment of Diagnostic Imaging, Radboud University Medical Centre, Nijmegen, Netherlands.
Julia Camps-HerreroRibera Salud Hospitals, Valencia, Spain.
Mami IimaDepartment of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan. mamiiima1@gmail.com.ORCID http://orcid.org/0000-0002-1991-2494
EUSOBI International Breast Diffusion-Weighted Imaging working group

Funding

Breast Cancer Intravoxel-incoherent-motion MRI Multisite (BRIMM) Study - Resubmission - 1UH3CA239861 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SIGMUND, ERIC EDWARD, THAKUR, SUNITHA BAI · 2023 to 2025
$1.6M
Breast Cancer Intravoxel-incoherent-motion MRI Multisite (BRIMM) Study - Resubmission - 1UG3CA239861 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SIGMUND, ERIC EDWARD, THAKUR, SUNITHA BAI · 2021 to 2022
$771k
NCI NIH HHS UG3 CA239861NCI NIH HHS UH3 CA239861
6 · The paper itself

Abstract

objectivesThis study by the EUSOBI International Breast Diffusion-weighted Imaging (DWI) working group aimed to evaluate the current and future applications of advanced DWI in breast imaging.

methodsA literature search and a comprehensive survey of EUSOBI members to explore the clinical use and potential of advanced DWI techniques and a literature search were involved. Advanced DWI approaches such as intravoxel incoherent motion (IVIM), diffusion kurtosis imaging (DKI), and diffusion tensor imaging (DTI) were assessed for their current status and challenges in clinical implementation.

resultsAlthough a literature search revealed an increasing number of publications and growing academic interest in advanced DWI, the survey revealed limited adoption of advanced DWI techniques among EUSOBI members, with 32% using IVIM models, 17% using non-Gaussian diffusion techniques for kurtosis analysis, and only 8% using DTI. A variety of DWI techniques are used, with IVIM being the most popular, but less than half use it, suggesting that the study identified a gap between the potential benefits of advanced DWI and its actual use in clinical practice.

conclusionThe findings highlight the need for further research, standardization and simplification to transition advanced DWI from a research tool to regular practice in breast imaging. The study concludes with guidelines and recommendations for future research directions and clinical implementation, emphasizing the importance of interdisciplinary collaboration in this field to improve breast cancer diagnosis and treatment. CLINICAL RELEVANCE STATEMENT: Advanced DWI in breast imaging, while currently in limited clinical use, offers promising improvements in diagnosis, staging, and treatment monitoring, highlighting the need for standardized protocols, accessible software, and collaborative approaches to promote its broader integration into routine clinical practice. KEY POINTS: Increasing number of publications on advanced DWI over the last decade indicates growing research interest. EUSOBI survey shows that advanced DWI is used primarily in research, not extensively in clinical practice. More research and standardization are needed to integrate advanced DWI into routine breast imaging practice.

Indexed as

Breast NeoplasmsDiffusion Magnetic Resonance ImagingBreastDiffusion Tensor ImagingFemaleHumansBreast neoplasmsDiffusion magnetic resonance imagingSurveys and questionnaires

Identifiers

PMID39379708
PMCPMC11914331

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.