Evidence map›Paper›PMID 39379493›Full record

ReviewNature reviews. Neurology2024

Coeliac disease as a model for understanding multiple sclerosis.

Natalia Drosu, Kjetil Bjornevik, Marianna Cortese, Michael Levy, Ludvig M Sollid

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. CD4Science translational medicine · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Natalia DrosuDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Kjetil BjornevikDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.ORCID 0000-0002-2892-6986
Marianna CorteseDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Michael LevyDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Ludvig M SollidInstitute of Clinical Medicine, University of Oslo, Oslo, Norway. l.m.sollid@medisin.uio.no.ORCID 0000-0001-8860-704X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The genetic architecture of multiple sclerosis (MS) is similar to that of coeliac disease, with human leukocyte antigen (HLA) being the greatest genetic determinant in both diseases. Furthermore, similar to the involvement of gluten in coeliac disease, Epstein-Barr virus (EBV) infection is now widely considered to be an important environmental factor in MS. The molecular basis for the HLA association in coeliac disease is well defined, and B cells have a clear role in antigen presentation to gluten-specific CD4

Indexed as

Celiac DiseaseMultiple SclerosisB-LymphocytesEpstein-Barr Virus InfectionsHerpesvirus 4, HumanHLA AntigensHumansHLA Antigens

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.