Evidence map›Paper›PMID 39379466›Full record

ArticleHypertension research : official journal of the Japanese Society of Hypertension2025

Early-onset preeclampsia/gestational hypertension may be associated with a low incidence of cerebral palsy at 3 years old in singleton very low-birth-weight infants born at 28-31 weeks of gestation (EOPE-DQ study): a multi-center retrospective cohort study in 2013-2016.

Akihide Ohkuchi, Hirotada Suzuki, Asako Kanai, Masashi Fukuda, Yoshinori Takeda, Chiho Fuseya, Makoto Nomiyama, Takafumi Ushida, Kazushi Watanabe, Yumi Kono and 3 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Akihide OhkuchiDepartment of Obstetrics and Gynecology, Jichi Medical University School of Medicine, Shimotsuke-shi, Tochigi, 329-0498, Japan. okuchi@jichi.ac.jp.
Hirotada SuzukiDepartment of Obstetrics and Gynecology, Jichi Medical University School of Medicine, Shimotsuke-shi, Tochigi, 329-0498, Japan.
Asako KanaiDepartment of Obstetrics and Gynecology, Asahikawa Medical University, Asahikawa, Japan.
Masashi FukudaDepartment of Obstetrics and Gynecology, NHO Nagasaki Medical Center, Nagasaki, Japan.
Yoshinori TakedaDepartment of Obstetrics and Gynecology, Nara Medical University, Nara, Japan.
Chiho FuseyaDepartment of Obstetrics and Gynecology, Shinshu University School of Medicine, Nagano, Japan.
Makoto NomiyamaDepartment of Obstetrics and Gynecology, National Hospital Organization, Saga Hospital, Saga, Japan.
Takafumi UshidaDepartment of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Kazushi WatanabeDepartment of Obstetrics and Gynecology, Aichi Medical University School of Medicine, Nagoya, Aichi, Japan.
Yumi KonoDepartment of Pediatrics, Jichi Medical University, Tochigi, Japan.
Katsuhiko NaruseDepartment of Obstetrics and Gynecology, Dokkyo Medical University, Tochigi, Japan.
Hiroyuki SekiDepartment of Obstetrics and Gynecology, Saitama Medical Center, Saitama Medical University, Saitama, Japan.
Shigeru SaitoDepartment of Obstetrics and Gynecology, University of Toyama, Toyama, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Our aim was to evaluate the effects of any types of hypertensive disorders of pregnancy (HDP) on the development of either cerebral palsy (CP) or developmental delay (DD) at 3 years old in singleton very low-birth-weight (VLBW) infants born at 24-31 weeks of gestation. This was a retrospective cohort study of VLBW infants born at 24-31 weeks in 2013-2016 in Japan, using a nationwide obstetrical database, and Neonatal Research Network Japan (NRNJ) Database, accompanied by a secondary survey of women complicated with HDP (EOPE-DQ study). In 529 candidates for long-term follow-up in 7 tertiary centers, the percentage undergoing follow-up for CP at 3 years old was 56.1%, and the percentage receiving follow-up for DD at 3 years old was 54.1%. The percentage of PE/SPE/GH was significantly lower in infants with CP than in controls (1/22 [4.5%] vs. 66/274 [24.1%], p = 0.034); especially, in infants born at 28-31 weeks, the percentage of PE/SPE/GH was significantly lower in infants with CP than in controls (0/13 [0%] vs. 44/151 [29.1%], p = 0.021). The percentage of PE/SPE/GH was not different between infants with DD and controls (9/49 [18.4%] vs. 54/237 [22.8%], p = 0.574). The percentage of composite risk factors (either bronchopulmonary dysplasia at a postmenstrual age of 36 weeks, intraventricular hemorrhage, hypoxic ischemic encephalopathy, sepsis, necrotizing enterocolitis, or periventricular leukomalacia) was significantly higher in infants with DD than in controls. In conclusion, PE/SPE/GH around 30 weeks may be associated with a low incidence of CP.

Indexed as

Cerebral PalsyHypertension, Pregnancy-InducedInfant, Very Low Birth WeightPre-EclampsiaAdultChild, PreschoolDevelopmental DisabilitiesFemaleGestational AgeHumansIncidenceInfant, NewbornJapanMalePregnancyRetrospective Studiescerebral palsydevelopmental delaygestational hypertensionpreeclampsiavery preterm birth

Identifiers

PMID39379466

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.