ArticleNature communications2024
Multiomic single-cell sequencing defines tissue-specific responses in Stevens-Johnson syndrome and toxic epidermal necrolysis.
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Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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23citing papers in PubMed, 1 pooled it
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systemic Therapy for Paediatric Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Systematic Review of Current Evidence and Limitations.Journal of paediatrics and child health · 2026Pooled it
- Combined immune modulation reveals carbamazepine-associated CD8Archives of toxicology · 2026Article
- New Insights Into Immunomodulatory Strategies for Drug Hypersensitivity Reactions: An EAACI Task Force Report.Clinical and translational allergy · 2026Review
- Toxic Epidermal Necrolysis Mimicking Severe Acute Graft-Versus-Host Disease After Allogeneic Hematopoietic Stem Cell Transplantation: A Diagnostic Challenge.Journal of clinical medicine · 2026Article
- JAK inhibition may prevent drug hypersensitivity reactions.JCI insight · 2026Article
- Co-evolved Partners of Immunity: A Trait-Based Map of Human Keystone Organisms.bioRxiv : the preprint server for biology · 2026Article
- Immunological and Inflammatory Characteristics of Severe Cutaneous Adverse Drug Reactions: A Retrospective Study.International journal of general medicine · 2026Article
- Immunological and molecular signatures of carbamazepine-induced maculopapular exanthema.Frontiers in immunology · 2026Article
- Fulminant toxic epidermal necrolysis induced by pucotenlimab in a patient with lung adenocarcinoma: a case report.Frontiers in oncology · 2026Article
- Carbamazepine activates private self and viral reactive TCRs through a drug-permissive HLA-B cleft.Frontiers in immunology · 2026Article
- Keystone Epitope Theory: Implications for Hypersensitivity, Autoimmunity, and Transplantation.Pathogens & immunity · 2026Review
- HLA-B Alleles With Shared Peptide Binding Specificities Define Global Risk of Co-trimoxazole-Induced Severe Cutaneous Adverse Drug Reactions.The journal of allergy and clinical immunology. In practice · 2025Article
- Immune checkpoint inhibitor-induced toxic epidermal necrolysis responding to repeated dosing of adjuvant therapy with etanercept.JAAD case reports · 2025Article
- Inhibition of formyl peptide receptor-1-mediated cell death as a therapy for lethal cutaneous drug reactions in preclinical models.Nature communications · 2025Article
- Updates in the pathogenesis of SJS/TEN.Allergology international : official journal of the Japanese Society of Allergology · 2025Review
- Adaptive-like NK cell responses to influenza correlate with humoral immunity and are influenced by age and sex.bioRxiv : the preprint server for biology · 2025Article
- Targeting the Galectin-7/TRPM2/ZnAllergy · 2025Article
- Single-Cell RNA Sequencing Revealed Functional Conjunctival Keratinocytes Loss via TGF-β-Wnt/β-Catenin Signaling in Sjögren's Syndrome Related Dry Eye.Investigative ophthalmology & visual science · 2025Article
- Proteomic signatures of type 2 diabetes predict the incidence of coronary heart disease.Cardiovascular diabetology · 2025Article
- Proteins lead the way: JAK inhibitors as a new treatment option in toxic epidermal necrolysis.Signal transduction and targeted therapy · 2025Article
Corrections and comments
- Update of
Authors and funding
27 authors.
Andrew GibsonInstitute for Immunology and Infectious Diseases, Murdoch University, Perth, Australia.
Ramesh RamInstitute for Immunology and Infectious Diseases, Murdoch University, Perth, Australia.
Rama GangulaDepartment of Medicine, Vanderbilt University Medical Centre, Nashville, USA.
Yueran LiInstitute for Immunology and Infectious Diseases, Murdoch University, Perth, Australia.
Eric MukherjeeDepartment of Medicine, Vanderbilt University Medical Centre, Nashville, USA.ORCID 0000-0001-8715-1378
Amy M PalubinskyDepartment of Medicine, Vanderbilt University Medical Centre, Nashville, USA.
Chelsea N CampbellDepartment of Medicine, Vanderbilt University Medical Centre, Nashville, USA.
Michael ThorneInstitute for Immunology and Infectious Diseases, Murdoch University, Perth, Australia.
Katherine C KonvinseDepartment of Medicine, Vanderbilt University Medical Centre, Nashville, USA.
Phuti ChoshiDepartment of Medicine, Groote Schuur Hospital, Cape Town, South Africa.
Pooja DeshpandeInstitute for Immunology and Infectious Diseases, Murdoch University, Perth, Australia.
Sarah PedrettiAllergy and Immunology Unit, University of Cape Town Lung Institute, Cape Town, South Africa.
Mark W FearSchool of Biomedical Sciences, University of Western Australia, Perth, Australia.ORCID 0000-0003-3163-4666
Fiona M WoodSchool of Biomedical Sciences, University of Western Australia, Perth, Australia.
Richard T O'NeilRalph H Johnson VA Medical Center, Medical University of South Carolina, Charleston, USA.ORCID 0000-0002-9734-2343
Celestine N WanjallaDepartment of Medicine, Vanderbilt University Medical Centre, Nashville, USA.ORCID 0000-0001-9159-5414
Spyros A KalamsDepartment of Medicine, Vanderbilt University Medical Centre, Nashville, USA.ORCID 0000-0003-0098-7995
Silvana GaudieriInstitute for Immunology and Infectious Diseases, Murdoch University, Perth, Australia.
Rannakoe J LehloenyaDepartment of Medicine, University of Cape Town, Cape Town, South Africa.ORCID 0000-0002-1281-1789
Samuel S BailinDepartment of Medicine, Vanderbilt University Medical Centre, Nashville, USA.
Abha ChopraInstitute for Immunology and Infectious Diseases, Murdoch University, Perth, Australia.
Jason A TrubianoThe Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia.
AUS-SCAR Consortium
Jonny G PeterDepartment of Medicine, Groote Schuur Hospital, Cape Town, South Africa.ORCID 0000-0002-2658-0723
AFRiSCAR Consortium
Simon A MallalInstitute for Immunology and Infectious Diseases, Murdoch University, Perth, Australia.ORCID 0000-0002-7036-1309
Elizabeth J PhillipsInstitute for Immunology and Infectious Diseases, Murdoch University, Perth, Australia. elizabeth.j.phillips@vumc.org.ORCID 0000-0002-7623-3383
Funding
Tennessee CFAR: Implementation of Culturally Responsive Trauma-Informed Care with Youth with HIV in Memphis, TNP30AI110527 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI John Koethe · 2015 to 2026
$27.5MNATIENS: A Phase III Randomized Double Blinded Study to Determine the Mechanisms and Optimal Management of Stevens-Johnson Syndrome and Toxic Epidermal NecrolysisU01AI154659 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PHILLIPS, ELIZABETH · 2020 to 2025
$15.5MUnderstanding and preventing HLA-associated drug reactionsP50GM115305 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PHILLIPS, ELIZABETH, RODEN, DAN M · 2015 to 2019
$13.0MGenetic risk and long-term outcomes associated with Drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in survivorsR01HG010863 · NHGRI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PHILLIPS, ELIZABETH · 2019 to 2022
$3.1MHIV-associated Tuberculosis Training Program (HATTP)D43TW010559 · FIC · UNIVERSITY OF CAPE TOWN · PI Graeme Ayton Meintjes · 2017 to 2026
$3.0MImmune-mediated adverse drug reactions to HIV and TB treatments in South Africa: predict, prevent and improve long-term outcomes (IMARI SA study)R01AI152183 · NIAID · UNIVERSITY OF CAPE TOWN · PI MEINTJES, GRAEME AYTON, PHILLIPS, ELIZABETH · 2020 to 2025
$1.6MIMmune-mediated Adverse drug Reactions In African HIV endemic setting (IMARI-SA study)K43TW011178 · FIC · UNIVERSITY OF CAPE TOWN LUNG INSTITUTE · PI PETER, JONATHAN · 2018 to 2022
$648kSingle Cell definition of pathogenic T cells in Drug-induced Stevens-Johnson-Syndrome/Toxic epidermal necrolysisR21AI139021 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PHILLIPS, ELIZABETH · 2018 to 2019
$435kStevens Johnson Syndrome/Toxic Epidermal Necrolysis (SJS/TEN) 2023R13AR082704 · NIAMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PHILLIPS, ELIZABETH · 2023 to 2023
$45kBlocking lung cancer progression with peptide delivering cell therapy platformsIK2BX004585 · VA · VETERANS HEALTH ADMINISTRATION · PI O'NEIL, RICHARD THOMAS · 2019 to 2023
–BLRD VA IK2 BX004585Department of Health | National Health and Medical Research Council (NHMRC) GNT1123499Department of Health | National Health and Medical Research Council (NHMRC) GNT2028952FIC NIH HHS D43 TW010559FIC NIH HHS K43 TW011178NHGRI NIH HHS R01 HG010863NIAID NIH HHS P30 AI110527NIAID NIH HHS R01 AI152183NIAID NIH HHS R21 AI139021NIAID NIH HHS U01 AI154659NIAMS NIH HHS R13 AR082704NIGMS NIH HHS P50 GM115305U.S. Department of Health & Human Services | National Institutes of Health (NIH) 2 D43 TW010559U.S. Department of Health & Human Services | National Institutes of Health (NIH) K43 TW011178-01U.S. Department of Health & Human Services | National Institutes of Health (NIH) P50GM115305U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01AI152183U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01HG010863U.S. Department of Health & Human Services | National Institutes of Health (NIH) R21AI139021U.S. Department of Health & Human Services | National Institutes of Health (NIH) U01AI154659
Abstract
Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) is a rare but life-threatening cutaneous drug reaction mediated by human leukocyte antigen (HLA) class I-restricted CD8
Indexed as
CD8-Positive T-LymphocytesKeratinocytesReceptors, Antigen, T-CellSingle-Cell AnalysisStevens-Johnson SyndromeAntigens, Differentiation, T-LymphocyteFemaleGranzymesHistocompatibility Antigens Class IHumansMacrophagesMalePerforinSkinT-Lymphocytes, CytotoxicTranscriptomeAntigens, Differentiation, T-LymphocyteGNLY protein, humanGranzymesGZMB protein, humanHistocompatibility Antigens Class IPerforinReceptors, Antigen, T-Cell
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