Evidence map›Paper›PMID 39379106›Full record

ArticleRNA (New York, N.Y.)2024

Site-blocking antisense oligonucleotides as a mechanism to fine-tune MeCP2 expression.

Amanda M Vanderplow, Grace E Dodis, Yewon Rhee, Jakub J Cikowski, Sonia Gonzalez, Mackenzie L Smith, Rocco G Gogliotti

Abstract read
In one paragraph

Article in RNA (New York, N.Y.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. RNA therapeutics: current status and future directions.Signal transduction and targeted therapy · 2026
    Review
  2. Review
  3. The Versatile Applications of Antisense Oligonucleotides in Modern Medicine.International journal of molecular sciences · 2026
    Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Amanda M VanderplowDepartment of Molecular Pharmacology and Neuroscience, Loyola University Chicago, Maywood, Illinois 60153, USA.ORCID http://orcid.org/0000-0002-2659-8587
Grace E DodisDepartment of Molecular Pharmacology and Neuroscience, Loyola University Chicago, Maywood, Illinois 60153, USA.
Yewon RheeDepartment of Molecular Pharmacology and Neuroscience, Loyola University Chicago, Maywood, Illinois 60153, USA.
Jakub J CikowskiDepartment of Molecular Pharmacology and Neuroscience, Loyola University Chicago, Maywood, Illinois 60153, USA.ORCID http://orcid.org/0009-0001-3811-3807
Sonia GonzalezDepartment of Molecular Pharmacology and Neuroscience, Loyola University Chicago, Maywood, Illinois 60153, USA.
Mackenzie L SmithDepartment of Molecular Pharmacology and Neuroscience, Loyola University Chicago, Maywood, Illinois 60153, USA.
Rocco G GogliottiDepartment of Molecular Pharmacology and Neuroscience, Loyola University Chicago, Maywood, Illinois 60153, USA rgogliotti@luc.edu.

Funding

A precision medicine approach to Rett SyndromeR01NS112171 · NINDS · LOYOLA UNIVERSITY CHICAGO · PI GOGLIOTTI, ROCCO GEORGE · 2020 to 2024
$1.7M
miRNA site-blocking ASOs as MeCP2 targeted therapeuticsR21HD111864 · NICHD · LOYOLA UNIVERSITY CHICAGO · PI GOGLIOTTI, ROCCO GEORGE · 2023 to 2024
$424k
Targeting MeCP2-Associated Disorders with miRNA Site-Blocking OligonucleotidesF32HD113386 · NICHD · LOYOLA UNIVERSITY CHICAGO · PI VANDERPLOW, AMANDA · 2024 to 2025
$136k
The interplay of the heat shock cascade and Rett syndromeF31NS134246 · NINDS · LOYOLA UNIVERSITY CHICAGO · PI Sonia Gonzalez · 2024 to 2026
$105k
NICHD NIH HHS F32 HD113386NICHD NIH HHS R21 HD111864NINDS NIH HHS F31 NS134246NINDS NIH HHS R01 NS112171
6 · The paper itself

Abstract

Rett syndrome (RTT) is a neurodevelopmental disorder caused by loss-of-function mutations in the

Indexed as

3' Untranslated RegionsMethyl-CpG-Binding Protein 2MicroRNAsOligonucleotides, AntisenseRett SyndromeAnimalsBrain-Derived Neurotrophic FactorGene Expression RegulationHumansMiceMutation3' Untranslated RegionsBrain-Derived Neurotrophic FactorMECP2 protein, humanMecp2 protein, mouseMethyl-CpG-Binding Protein 2MicroRNAsOligonucleotides, AntisenseantisenseMeCP2oligonucleotidesRett syndromesite-blocking

Identifiers

PMID39379106
PMCPMC11571808

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.