Evidence map›Paper›PMID 39379061›Full record

Trial reportInternational wound journal2024

Combination therapy of negative pressure wound therapy and antibiotic-loaded bone cement for accelerating diabetic foot ulcer healing: A prospective randomised controlled trial.

Meifang Zhong, Jiawei Guo, Mulan Qahar, Guangtao Huang, Jun Wu

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in International wound journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Pooled it
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  7. Review
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  16. Ischial Pressure Ulcer Reconstruction: A Critical Review of the Paradigm Shift From Wound Coverage to Functional Restoration.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Meifang ZhongDepartment of Burn and Plastic Surgery, Shenzhen Second People' s Hospital (The First Hospital Affiliated to Shenzhen University), Shenzhen, China.ORCID https://orcid.org/0009-0008-1360-7991
Jiawei GuoDepartment of Hand and Foot Surgery, Shenzhen Second People' s Hospital (The First Hospital Affiliated to Shenzhen University), Shenzhen, China.
Mulan QaharShenzhen Institute of Translational Medicine, Shenzhen, China.
Guangtao HuangDepartment of Burn and Plastic Surgery, Shenzhen Second People' s Hospital (The First Hospital Affiliated to Shenzhen University), Shenzhen, China.
Jun WuDepartment of Burn and Plastic Surgery, Shenzhen Second People' s Hospital (The First Hospital Affiliated to Shenzhen University), Shenzhen, China.

Funding

Burns, Plastic Surgery, and Wound Repair, Guangtao Huang Scientific Research Startup Fund 4004050National Key Clinical Specialty ([2023] No. 25) 2000022Shenzhen Science and Technology Program JCYJ20230807115121043The Project funded by China Postdoctoral Science Foundation 2023M742413
6 · The paper itself

Abstract

Negative pressure wound therapy (NPWT) and antibiotic-loaded bone cement (ALBC) are commonly used treatments for diabetic foot ulcers (DFUs). However, the combined efficacy of these two modalities remains unclear. This clinical study aimed to assess the effectiveness and underlying mechanisms of NPWT&ALBC in the management of DFUs. A total of 28 patients were recruited, 16 of whom served as controls and received only NPWT, whilst 12 received NPWT&ALBC. Both groups underwent wound repair surgery following the treatments. Blood samples were obtained to detect infections and inflammation. Wound tissue samples were also collected before and after the intervention to observe changes in inflammation, vascular structure and collagen through tissue staining. Compared with the NPWT group, the NPWT&ALBC group exhibited a superior wound bed, which was characterised by reduced inflammation infiltration and enhanced collagen expression. Immunostaining revealed a decrease in IL-6 levels and an increase in α-SMA, CD68, CD206 and collagen I expression. Western blot analysis demonstrated that NPWT&ALBC led to a decrease in inflammation levels and an increase in vascularization and collagen content. NPWT&ALBC therapy tends to form a wound bed with increased vascularization and M2 macrophage polarisation, which may contribute to DFUs wound healing.

Indexed as

Anti-Bacterial AgentsBone CementsDiabetic FootNegative-Pressure Wound TherapyWound HealingAgedCombined Modality TherapyFemaleHumansMaleMiddle AgedProspective StudiesTreatment OutcomeAnti-Bacterial AgentsBone Cementsantibiotic‐loaded bone cementchronic foot ulcerclinical therapynegative pressure wound therapytype 2 diabeteswound bed preparation

Identifiers

PMID39379061
PMCPMC11461018

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.