Evidence map›Paper›PMID 39378996›Full record

ArticleProceedings. Biological sciences2024

Relaxed selection in evolution of genes regulating limb development gives clue to variation in forelimb morphology of cetaceans and other mammals.

Valeriia Telizhenko, Carolin Kosiol, Michael R McGowen, Pavel Gol'din

Abstract read
In one paragraph

Article in Proceedings. Biological sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Adaptive evolution ofZoological research · 2025
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Valeriia TelizhenkoSchmalhausen Institute of Zoology , Kyiv, Ukraine.ORCID 0000-0002-8571-6053
Carolin KosiolUniversity of St Andrews , St Andrews, Fife KY16 9TF, UK.
Michael R McGowenDepartment of Vertebrate Zoology, Smithsonian National Museum of Natural History , Washington, DC 20560, USA.
Pavel Gol'dinSchmalhausen Institute of Zoology , Kyiv, Ukraine.ORCID 0000-0001-6118-1384

Funding

National Research Foundation of Ukraine
6 · The paper itself

Abstract

Cetaceans have evolved unique limb structures, such as flippers, due to genetic changes during their transition to aquatic life. However, the full understanding of the genetic and evolutionary mechanisms behind these changes is still developing. By examining 25 limb-related protein-coding genes across various mammalian species, we compared genetic changes between aquatic mammals, like whales, and other mammals with unique limb structures such as bats, rodents and elephants. Our findings revealed significant modifications in limb-related genes, including variations in the Hox,

Indexed as

CetaceaForelimbMammalsAnimalsBiological EvolutionEvolution, MolecularSelection, Geneticaquatic mammalscetaceansGDF5Hox geneslimb evolutionrelaxed selection

Identifiers

PMID39378996
PMCPMC11606503

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.