ReviewJournal of muscle research and cell motility1985
The thin filaments of smooth muscles.
Review in Journal of muscle research and cell motility, 1985. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
54 citing papers in PubMed, 195 citations in OpenAlex.
- Smooth muscle ultrastructure - still shrouded in mystery?Protoplasma · 2026Review
- Smooth muscle contractile cytoskeleton in health and disease.Journal of muscle research and cell motility · 2026Review
- MBNL loss of function in smooth muscle as a model for myotonic dystrophy associated gastrointestinal dysmotility.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Membrane adhesion junctions regulate airway smooth muscle phenotype and function.Physiological reviews · 2023Review
- Comparative Microarray Analysis of Proliferating and Differentiating Murine ENS Progenitor Cells.Stem cells international · 2016Article
- Diffusion of myosin light chain kinase on actin: A mechanism to enhance myosin phosphorylation rates in smooth muscle.The Journal of general physiology · 2015Article
- Acrylodan-labeled smooth muscle tropomyosin reports differences in the effects of troponin and caldesmon in the transition from the active state to the inactive state.Biochemistry · 2011Article
- Biochemistry of smooth muscle myosin light chain kinase.Archives of biochemistry and biophysics · 2011Review
- Distinct effects of contraction agonists on the phosphorylation state of cofilin in pulmonary artery smooth muscle.Advances in pharmacological sciences · 2008Article
- Hypotonic activation of volume-sensitive outwardly rectifying anion channels (VSOACs) requires coordinated remodeling of subcortical and perinuclear actin filaments.The Journal of membrane biology · 2005Article
- Canine mesenteric artery and vein convey no difference in the content of major contractile proteins.BMC physiology · 2002Article
- Contractile properties and proteins of smooth muscles of a calponin knockout mouse.The Journal of physiology · 2000Article
- A role for serine-175 in modulating the molecular conformation of calponin.The Biochemical journal · 2000Article
- Calcium transients and the effect of a photolytically released calcium chelator during electrically induced contractions in rabbit rectococcygeus smooth muscle.Biophysical journal · 1998Article
- Location and functional characterization of myosin contact sites in smooth muscle caldesmon.The Biochemical journal · 1997Article
- Both N-terminal myosin-binding and C-terminal actin-binding sites on smooth muscle caldesmon are required for caldesmon-mediated inhibition of actin filament velocity.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Three-dimensional image reconstruction of reconstituted smooth muscle thin filaments: effects of caldesmon.Biophysical journal · 1997Article
- Affinity and structure of complexes of tropomyosin and caldesmon domains.Biophysical journal · 1996Article
- Modulation of gelsolin-induced actin-filament severing by caldesmon and tropomyosin and the effect of these proteins on the actin activation of myosin Mg(2+)-ATPase activity.The Biochemical journal · 1996Article
- Filamin and gelsolin influence Ca(2+)-sensitivity of smooth muscle thin filaments.Journal of muscle research and cell motility · 1994Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Contraction in vertebrate smooth and striated muscles results from the interaction of the actin filaments with crossbridges arising from the myosin filaments. The functions of the actin based thin filaments are (1) interaction with myosin to produce force; (2) regulation of force generation in response to Ca2+ concentration; and (3) transmission of the force to the ends of the cell. The major protein components of smooth muscle thin filaments are actin, tropomyosin and caldesmon, present in molar ratios of 28:4:1 respectively. Other smooth muscle proteins which may be associated with the thin filaments in the cell are filamin, vinculin, alpha-actinin, myosin light chain kinase and calmodulin. We have reviewed the structural and functional properties of these proteins and where possible we have suggested what their function and mechanism of action may be. We propose that actin and tropomyosin are involved in the force producing interaction with myosin, and that this interaction is controlled by a Ca2+-dependent mechanism involving caldesmon, tropomyosin and calmodulin. Vinculin, alpha-actinin and filamin appear to be involved in the attachment of the thin filaments to the cell membrane and their spatial organization within the cell. We conclude that the filaments of smooth muscles share many common properties with those from skeletal muscle, but that they are also quite distinct in terms of both their caldesmon based regulatory mechanism and their mode of organization into a contractile apparatus.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.