Evidence map›Paper›PMID 39378319›Full record

ArticleJournal of perinatal medicine2024

Mode of delivery and behavioral and neuropsychological outcomes in children at 10 years of age.

Andrew Massa, Zhixin Yang, Ryan Tamashiro, Oliver Isik, Ruth Landau, Caleb H Miles, Britta S Von Ungern-Sternberg, Andrew Whitehouse, Guohua Li, Craig E Pennell and 1 more

Abstract read
In one paragraph

Article in Journal of perinatal medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Andrew MassaDepartment of Anesthesiology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Zhixin YangDepartment of Anesthesiology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Ryan TamashiroDepartment of Anesthesiology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Oliver IsikDepartment of Anesthesiology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Ruth LandauDepartment of Anesthesiology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Caleb H MilesDepartment of Biostatistics, Mailman School of Public Health, New York, NY, USA.
Britta S Von Ungern-SternbergDivision of Emergency Medicine, Anaesthesia and Pain Medicine, Medical School, The University of Western Australia, Perth, Australia.
Andrew WhitehouseKids Research Institute Australia, University of Western Australia, Perth, Australia.
Guohua LiDepartment of Anesthesiology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Craig E PennellDepartment of Obstetrics and Gynaecology, School of Medicine and Public Health, College of Health, Medicine and Wellbeing, The University of Newcastle, Newcastle, Australia.
Caleb IngDepartment of Anesthesiology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.ORCID https://orcid.org/0000-0001-5917-9234

Funding

Prenatal Exposure to Anesthesia and Subsequent Neurodevelopmental DisordersR01HS026493 · AHRQ · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ING, CALEB · 2018 to 2022
$1.6M
AHRQ HHS R01 HS026493
6 · The paper itself

Abstract

objectivesPrevious studies have reported that mode of delivery, particularly cesarean delivery (CD), is associated with neurodevelopmental outcomes in children. This study evaluates behavioral and neuropsychological test scores in children based on mode of delivery.

methodsChildren enrolled in the Raine Study from Western Australia, born between 1989 and 1992 by instrumental vaginal delivery (IVD), elective CD, and non-elective CD, were compared to those with spontaneous vaginal delivery (SVD). The primary outcome was the Child Behavior Checklist (CBCL) administered at age 10. Secondary outcomes included evaluations of language, motor function, cognition, and autistic traits. Multivariable linear regression was used to evaluate score differences by mode of delivery adjusted for sociodemographic and clinical characteristics, and Poisson regression was used to evaluate for increased risk of clinical deficit.

resultsOf 2,855 children, 1770 (62.0 %) were delivered via SVD, 480 (16.8 %) via IVD, 346 (12.1 %) via elective CD, and 259 (9.1 %) via non-elective CD. Non-elective CD was associated with higher (worse) CBCL Internalizing (+2.09; 95 % CI 0.49, 3.96; p=0.01) scores, and elective CD was associated with lower (worse) McCarron Assessment of Neuromuscular Development (MAND) (-3.48; 95 % CI -5.61, -1.35; p=0.001) scores. Differences were not seen in other outcomes, and increased risk of clinical deficit was not observed with either the CBCL Internalizing or MAND scores.

conclusionsDifferences in behavior and motor function were observed in children delivered by CD, but given that score differences were not associated with increased incidence of clinical deficit, clinical significance may be limited.

Indexed as

Delivery, ObstetricCesarean SectionChildChild BehaviorChild DevelopmentFemaleHumansMaleNeuropsychological TestsPregnancyWestern Australiabehavioral deficitcesarean deliverymode of deliveryneurodevelopment

Identifiers

PMID39378319
PMCPMC11552485

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.