Evidence map›Paper›PMID 39378315›Full record

ArticleMolecular pharmaceutics2025

Innovative Microencapsulation of Polymyxin B for Enhanced Antimicrobial Efficacy via Coated Spray Drying.

Amal Yousfan, Arwa Omar Al Khatib, Afrah M H Salman, Mahmoud H Abu Elella, Glyn Barrett, Nicholas Michael, Mohammed Gulrez Zariwala, Hisham Al-Obaidi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular pharmaceutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Amal YousfanSchool of Pharmacy, University of Reading, Reading RG6 6AD, U.K.
Arwa Omar Al KhatibFaculty of Pharmacy, Al Ahliyya Amman University, Amman 19111, Jordan.
Afrah M H SalmanSchool of Biological Sciences, University of Reading, Reading RG6 6AD, U.K.
Mahmoud H Abu ElellaSchool of Pharmacy, University of Reading, Reading RG6 6AD, U.K.
Glyn BarrettSchool of Biological Sciences, University of Reading, Reading RG6 6AD, U.K.
Nicholas MichaelChemical Analysis Facility, University of Reading, Reading RG6 6AD, U.K.
Mohammed Gulrez ZariwalaCentre for Nutraceuticals, School of Life Sciences, University of Westminster, 115 New, Cavendish Street, London W1W 6UW, U.K.ORCID 0000-0001-9944-8451
Hisham Al-ObaidiSchool of Pharmacy, University of Reading, Reading RG6 6AD, U.K.ORCID 0000-0001-9735-0303

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aims to develop an innovative microencapsulation method for coated Polymyxin B, utilizing various polysaccharides such as hydroxypropyl β-cyclodextrin, alginate, and chitosan, implemented through a three-fluid nozzle (3FN) spray drying process. High-performance liquid chromatography (HPLC) analysis revealed that formulations with a high ratio of sugar cage, hydroxypropyl β-cyclodextrin (HPβCD), and sodium alginate (coded as ALG

Indexed as

AlginatesAnti-Bacterial AgentsDrug CompoundingEscherichia coliMicrobial Sensitivity TestsPolymyxin BPseudomonas aeruginosa2-Hydroxypropyl-beta-cyclodextrinChitosanChromatography, High Pressure LiquidDrug LiberationParticle SizeSpectroscopy, Fourier Transform InfraredSpray Drying2-Hydroxypropyl-beta-cyclodextrinAlginatesAnti-Bacterial AgentsChitosanPolymyxin Bantibiofilm assaycore/shell structuremicroencapsulationpolymyxin BPseudomonas aeruginosathree-fluid nozzle spray drying

Identifiers

PMID39378315
PMCPMC11707731

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.