Evidence map›Paper›PMID 39378096›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

HCN1 hyperpolarization-activated cyclic nucleotide-gated channels enhance evoked GABA release from parvalbumin-positive interneurons.

Eric W Buss, Olivia M Lofaro, Anastasia Barnett, Felix Leroy, Bina Santoro, Steven A Siegelbaum, Tobias Bock

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Functional Alterations in Parvalbumin-Positive Interneurons after Traumatic Brain Injury in Somatosensory Cortex of Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Eric W BussDepartments of Neuroscience and Pharmacology, Kavli Institute for Brain Science, Zuckerman Mind Brain Behavior Institute, Columbia University Medical Center, New York, NY 10027.ORCID 0000-0003-0473-4717
Olivia M LofaroDepartments of Neuroscience and Pharmacology, Kavli Institute for Brain Science, Zuckerman Mind Brain Behavior Institute, Columbia University Medical Center, New York, NY 10027.
Anastasia BarnettDepartments of Neuroscience and Pharmacology, Kavli Institute for Brain Science, Zuckerman Mind Brain Behavior Institute, Columbia University Medical Center, New York, NY 10027.
Felix LeroyDepartments of Neuroscience and Pharmacology, Kavli Institute for Brain Science, Zuckerman Mind Brain Behavior Institute, Columbia University Medical Center, New York, NY 10027.ORCID 0000-0003-1715-3233
Bina SantoroDepartments of Neuroscience and Pharmacology, Kavli Institute for Brain Science, Zuckerman Mind Brain Behavior Institute, Columbia University Medical Center, New York, NY 10027.
Steven A SiegelbaumDepartments of Neuroscience and Pharmacology, Kavli Institute for Brain Science, Zuckerman Mind Brain Behavior Institute, Columbia University Medical Center, New York, NY 10027.ORCID 0000-0002-0242-7505
Tobias BockDepartments of Neuroscience and Pharmacology, Kavli Institute for Brain Science, Zuckerman Mind Brain Behavior Institute, Columbia University Medical Center, New York, NY 10027.ORCID 0000-0002-7734-1183

Funding

Role of HCN1 Channels in the Function and Malfunction of Parvalbumin Positive InterneuronsR01NS123648 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SIEGELBAUM, STEVEN A · 2021 to 2025
$2.0M
HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01NS123648NINDS NIH HHS R01 NS123648
6 · The paper itself

Abstract

Hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels generate the cationic I

Indexed as

CA1 Region, Hippocampalgamma-Aminobutyric AcidHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsInterneuronsMice, KnockoutParvalbuminsAnimalsInhibitory Postsynaptic PotentialsMaleMiceOptogeneticsPotassium ChannelsPresynaptic TerminalsPyramidal Cellsgamma-Aminobutyric AcidHcn1 protein, mouseHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsParvalbuminsPotassium ChannelsHCN channelhippocampusinterneuronparvalbuminsynapse

Identifiers

PMID39378096
PMCPMC11494348

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.