ArticleProceedings of the National Academy of Sciences of the United States of America2024
Injury-induced myosin-specific tissue-resident memory T cells drive immune checkpoint inhibitor myocarditis.
Abstract read
In one paragraph
Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Cytomegalovirus Latency Fuels Inflammation Following Myocardial Infarction.Circulation research · 2026Article
- Cardiac tertiary immune niches drive immune activation in immune checkpoint inhibitor myocarditis.Science advances · 2026Article
- FUNDC1-mediated mitochondrial quality control protects against immune checkpoint inhibitor-associated cardiac injury.Immunologic research · 2026Article
- Myocardial Immune Niches in Homeostasis and Inflammation.Immunological reviews · 2026Review
- Inhibition of the programmed death protein 1 immune checkpoint and the development of heart failure in the presence of prior cardiac ischaemia.Cardiovascular research · 2026Article
- Cross-reactive tissue-resident memory T lymphocytes-concepts, evidence, and open questions.Journal of translational medicine · 2026Review
- Tissue-resident memory T cells in organ transplantation: implications for immune homeostasis and graft outcomes.Inflammation and regeneration · 2026Review
- IRF9-dependent transcriptional regulation of SLC40A1 suppresses ferroptosis in dilated cardiomyopathy.Scientific reports · 2026Article
- Pathological mechanisms and treatment strategies for immune checkpoint inhibitor-associated myocarditis: insights from single-cell sequencing.Basic research in cardiology · 2026Review
- CXCR6Circulation · 2026Article
- Emerging Mechanisms and Therapeutic Strategies in Dilated Cardiomyopathy.Biomedicines · 2026Review
- Immune checkpoint inhibition and heart injury: molecular mechanisms and clinical challenges.ESC heart failure · 2026Review
- Mechanisms and biomarkers of immune checkpoint inhibitor-associated myocarditis: from T cell imbalance to multicellular crosstalk.Frontiers in immunology · 2026Review
- Understanding immune checkpoint inhibitors-related myocarditis: Mechanisms and targeted therapeutic pathways.Theranostics · 2026Review
- The role of the bidirectional regulatory network between immune cells and stromal cells in cardiac repair and fibrosis following myocardial infarction.Frontiers in immunology · 2026Review
- Cardiovascular toxicity induced by immune checkpoint inhibitors: mechanisms linking immune dysregulation and myocardial fibrosis.American journal of clinical and experimental immunology · 2026Review
- Inhibitory receptor states, immune homeostasis and the benefit-risk boundary of cancer checkpoint blockade.Frontiers in immunology · 2026Review
- Whole-heart 3D reconstruction of mouse CVB3 myocarditis reveals spatial and transcriptomic heterogeneity of immune foci.Cardiovascular research · 2025Article
- Review
- Cathepsin L as a dual-target to mitigate muscle wasting while enhancing anti-tumor efficacy of anti-PD-L1.Nature communications · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Hannah KalinoskiW. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205.ORCID 0000-0002-2732-0077
Abdel DaoudW. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205.
Vitali RusinkevichDepartment of Pathology, School of Medicine, Johns Hopkins University, Baltimore, MD 21205.ORCID 0000-0002-7215-1452
Ivana JurčováDepartment of Cardiology, Institute for Clinical and Experimental Medicine, Prague 140 21, Czech Republic.
Monica V TalorDepartment of Pathology, School of Medicine, Johns Hopkins University, Baltimore, MD 21205.
Robin A WelshDepartment of Pathology, School of Medicine, Johns Hopkins University, Baltimore, MD 21205.
David HughesDepartment of Pathology, School of Medicine, Johns Hopkins University, Baltimore, MD 21205.
Kateřina ZemanováDepartment of Clinical and Transplant Immunology, Institute for Clinical and Experimental Medicine, Prague 140 21, Czech Republic.
Ilja StřížDepartment of Clinical and Transplant Immunology, Institute for Clinical and Experimental Medicine, Prague 140 21, Czech Republic.
Jody E HooperDepartment of Pathology, School of Medicine, Johns Hopkins University, Baltimore, MD 21205.
Josef KautznerDepartment of Cardiology, Institute for Clinical and Experimental Medicine, Prague 140 21, Czech Republic.
Petr PeichlDepartment of Cardiology, Institute for Clinical and Experimental Medicine, Prague 140 21, Czech Republic.ORCID 0000-0002-5625-0071
Vojtěch MelenovskýDepartment of Cardiology, Institute for Clinical and Experimental Medicine, Prague 140 21, Czech Republic.ORCID 0000-0001-8921-7078
Taejoon WonDepartment of Pathology, School of Medicine, Johns Hopkins University, Baltimore, MD 21205.
Daniela Čiháková *W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205.ORCID 0000-0002-8713-2860
Funding
Training: Molecular & Cellular Bases of Infectious DiseasesT32AI007417 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Arturo Casadevall · 1994 to 2026
$11.9MMyeloid Cells are Critical in Inflammatory Heart DiseaseR01HL118183 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI CIHAKOVA, DANIELA · 2014 to 2023
$4.4MRole of CX3CR1 in the Pathogenesis of AtherosclerosisR01HL077406 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FONG, ALAN M · 2006 to 2010
$1.8MRole of Sca-1+Cardiac Fibroblasts in Inflammatory Heart Disease`R01HL136586 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI CIHAKOVA, DANIELA · 2018 to 2021
$1.6MPathogenesis of Immune checkpoint inhibitors-induced myocarditisR01CA289729 · NCI · JOHNS HOPKINS UNIVERSITY · PI Daniela Cihakova · 2025 to 2026
$1.1MThe Role of Checkpoint inhibitors in CIAF31AR077406 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI WOOD, MEGAN KAY · 2020 to 2022
$96k2018 Rhett Lundy Memorial Research Fellowship from the Myocarditis Foundation NAAmerican Heart Association (AHA) 19TPA34910007American Heart Association (AHA) 20TPA35490421American Heart Association (AHA) 23EIA1040103Delta Omega Scholarship NAGlobal Autoimmune Institute (GAI) NAHHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) F31AR077406HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL118183HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL136586HHS | NIH (NIH) 2T32AI007417-26HHS | NIH (NIH) 5T32AI007417-25Katherine E. Welsh Fellowship NAMatthew Poyner MVP Memorial Myocarditis Research Fund NANational Institute for Research of Metabolic and Cardiovascular Diseases LX22NPO5104NCI NIH HHS R01 CA289729NHLBI NIH HHS R01 HL118183NHLBI NIH HHS R01 HL136586NIAID NIH HHS T32 AI007417NIAMS NIH HHS F31 AR077406
Abstract
Cardiac myosin-specific (MyHC) T cells drive the disease pathogenesis of immune checkpoint inhibitor-associated myocarditis (ICI-myocarditis). To determine whether MyHC T cells are tissue-resident memory T (T
Indexed as
Immune Checkpoint InhibitorsMemory T CellsMyocarditisAnimalsAntigens, CDAntigens, Differentiation, T-LymphocyteCardiac MyosinsCD69 AntigensDisease Models, AnimalFemaleHumansLectins, C-TypeMaleMiceMice, Inbred C57BLMyocardiumAntigens, CDAntigens, Differentiation, T-LymphocyteCardiac MyosinsCD69 AntigensImmune Checkpoint InhibitorsLectins, C-TypeMyosinsPdcd1 protein, mouseProgrammed Cell Death 1 Receptorcardiac immunologyICI-myocarditisPD-1tissue-resident memory T cells
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.