Evidence map›Paper›PMID 39378083›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Native β-barrel substrates pass through two shared intermediates during folding on the BAM complex.

Thiago M A Dos Santos, Benjamin D Thomson, Melissa D Marquez, Lydia Pan, Tabasom H Monfared, Daniel E Kahne

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. A mechanism for substrate quality control in outer membrane protein assembly.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Review
  3. Structures of folding intermediates on BAM show diverse substrates fold by a conserved mechanism.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Bacterial cell envelope-targeting antibiotics.Nature reviews. Microbiology · 2026
    Review
  5. A fluorescent reporter and single-turnover kinetics reveal insight into BAM complex function.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Thiago M A Dos SantosDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138.ORCID 0000-0002-0648-6078
Benjamin D ThomsonDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138.ORCID 0000-0003-1603-9607
Melissa D MarquezDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138.ORCID 0000-0002-9867-1130
Lydia PanDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138.
Tabasom H MonfaredDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138.ORCID 0000-0001-7285-6420
Daniel E KahneDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138.

Funding

Project 3: Defining and defeating the mechanisms of outer membrane biogenesis in Gram-negative bacteriaU19AI158028 · NIAID · HARVARD MEDICAL SCHOOL · PI WALKER, SUZANNE · 2022 to 2025
$10.1M
Outer Membrane Biogenesis: New Antibiotic TargetsR01AI081059 · NIAID · HARVARD UNIVERSITY · PI Daniel Kahne · 2009 to 2026
$9.5M
HHMI (HHMI) Hanna H. Gray Postdoctoral FellowshipHHS | NIH (NIH) R01AI081059HHS | NIH (NIH) U19AI158028NIAID NIH HHS R01 AI081059NIAID NIH HHS U19 AI158028
6 · The paper itself

Abstract

The assembly of β-barrel proteins into membranes is mediated by the evolutionarily conserved β-barrel assembly machine (BAM) complex. In

Indexed as

Bacterial Outer Membrane ProteinsEscherichia coliEscherichia coli ProteinsProtein FoldingCysteineDisulfidesModels, MolecularSubstrate SpecificityBacterial Outer Membrane ProteinsBamA protein, E coliCysteineDisulfidesEscherichia coli Proteinsdisulfide crosslinkingfolding intermediatesgram-negative bacteriaouter membrane proteinsβ-barrel assembly machine

Identifiers

PMID39378083
PMCPMC11494362

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.