Evidence map›Paper›PMID 39378050›Full record

ArticleCancer discovery2025

The Evolutionary Forest of Pancreatic Cancer.

Katelyn M Mullen, Jungeui Hong, Marc A Attiyeh, Akimasa Hayashi, Hitomi Sakamoto, Zachary A Kohutek, Caitlin A McIntyre, Haochen Zhang, Alvin P Makohon-Moore, Amanda Zucker and 9 more

Abstract read
In one paragraph

Article in Cancer discovery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Oxidative stress and serum deprivation influence the evolution of newly formed tetraploid cells during tumorigenesis.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Current issues in molecular biology · 2025
    Article
  9. Article
  10. KRAS: the Achilles' heel of pancreas cancer biology.The Journal of clinical investigation · 2025
    Review
  11. Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Katelyn M MullenDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.ORCID 0000-0002-4894-855X
Jungeui HongDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.ORCID 0009-0009-5998-2102
Marc A AttiyehDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.ORCID 0000-0002-9949-1449
Akimasa HayashiDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.ORCID 0000-0002-7424-8127
Hitomi SakamotoDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.ORCID 0000-0002-5688-7806
Zachary A KohutekDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.ORCID 0009-0005-3220-6673
Caitlin A McIntyreDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.ORCID 0000-0002-7206-2433
Haochen ZhangDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.ORCID 0000-0002-8292-9491
Alvin P Makohon-MooreDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.ORCID 0000-0002-4781-3565
Amanda ZuckerDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.ORCID 0000-0002-9283-7072
Laura D WoodDivision of Gastrointestinal Pathology, Department of Pathology, Johns Hopkins Hospital, Baltimore, Maryland.ORCID 0000-0003-3096-652X
Matthew A MyersDepartment of Computer Science, Princeton University, Princeton, New Jersey.ORCID 0000-0002-9337-5180
Brian J ArnoldDepartment of Computer Science, Princeton University, Princeton, New Jersey.ORCID 0000-0002-8629-5465
Simone ZaccariaDepartment of Computer Science, Princeton University, Princeton, New Jersey.ORCID 0000-0002-5265-7392
Joanne F ChouBiostatistics and Epidemiology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York.ORCID 0000-0002-6866-2022
Marinela CapanuBiostatistics and Epidemiology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York.ORCID 0000-0003-4953-3193
Nicholas D SocciBioinformatics Core, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York.ORCID 0000-0002-8254-6925
Benjamin J RaphaelDepartment of Computer Science, Princeton University, Princeton, New Jersey.ORCID 0000-0003-1274-048X
Christine A Iacobuzio-DonahueDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.ORCID 0000-0002-4672-3023

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Transition to Metastatic State: Lung Cancer, Pancreatic Cancer and Brain MetastasisU2CCA233284 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI PE'ER, DANA · 2018 to 2022
$12.9M
Interrogating the Evolutionary Dynamics of Cancer for Clinical Benefit and ActionabilityR35CA220508 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI IACOBUZIO-DONAHUE, CHRISTINE A · 2018 to 2024
$6.9M
Comprehensive and Robust Tools for Analysis of Tumor Heterogeneity and EvolutionU24CA248453 · NCI · PRINCETON UNIVERSITY · PI Benjamin Raphael · 2020 to 2026
$4.7M
Experimental evolution of pancreatic cancerR00CA229979 · NCI · HACKENSACK UNIVERSITY MEDICAL CENTER · PI MAKOHON-MOORE, ALVIN · 2022 to 2024
$747k
Genetic Determinants of Evolutionary Trajectories and Clinical Course in Pancreatic CancerF31CA260796 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI MULLEN, KATELYN · 2021 to 2023
$140k
National Cancer Institute (NCI) CA220508NCI NIH HHS F31 CA260796NCI NIH HHS P30 CA008748NCI NIH HHS R00 CA229979NCI NIH HHS R35 CA220508NCI NIH HHS U24 CA248453NCI NIH HHS U2C CA233284
6 · The paper itself

Abstract

significanceAlthough the pancreatic cancer genome has been described, it has not been explored with respect to stages of diagnosis or treatment bottlenecks. We now describe and quantify the genomic features of PDAC in the context of evolutionary metrics and in doing so have identified a novel prognostic biomarker.

Indexed as

Carcinoma, Pancreatic DuctalPancreatic NeoplasmsBiomarkers, TumorGenomicsHumansPrognosisBiomarkers, Tumor

Identifiers

PMID39378050
PMCPMC11803399

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.