Evidence map›Paper›PMID 39377944›Full record

ArticleFunctional & integrative genomics2024

The mechanism of MMP14-positive tumor-associated fibroblast subsets in inhibiting PD-1 immunotherapy for esophageal cancer through exosomal tsRNA-10522.

Juzheng Wang, Chunlong Zheng, Jiayu Lu, Xinyao Xu, Guangyu Xiang, Jiahe Li, Jipeng Zhang, Xiaorong Mu, Qiang Lu

Abstract read
In one paragraph

Article in Functional & integrative genomics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Juzheng WangDepartment of Medical Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China.
Chunlong ZhengDepartment of Thoracic Surgery, Tangdu Hospital, Air Force Medical University, NO. 569 Xinsi Road, Xi'an, 710038, Shaanxi, China.
Jiayu LuBasic Medical College, Air Force Medical University, Xi'an, 710032, Shaanxi, China.
Xinyao XuCollege of Life Sciences, Northwest University, 229 Taibai North Road, Beilin District, Xi'an, 710069, Shaanxi, China.
Guangyu XiangBasic Medical College, Air Force Medical University, Xi'an, 710032, Shaanxi, China.
Jiahe LiBasic Medical College, Air Force Medical University, Xi'an, 710032, Shaanxi, China.
Jipeng ZhangDepartment of Thoracic Surgery, Tangdu Hospital, Air Force Medical University, NO. 569 Xinsi Road, Xi'an, 710038, Shaanxi, China.
Xiaorong MuDepartment of Pathology, Department of Pharmacy, Tangdu Hospital, Air Force Medical University, Xi'an, 710039, Shaanxi, China. mxr15084596796@163.com.
Qiang LuDepartment of Thoracic Surgery, Tangdu Hospital, Air Force Medical University, NO. 569 Xinsi Road, Xi'an, 710038, Shaanxi, China. luqiang@fmmu.edu.cn.

Funding

National Outstanding Youth Science Fund Project of National Natural Science Foundation of China 82002422
6 · The paper itself

Abstract

Esophageal cancer (EC) continues to pose a significant health risk. Cancer-associated fibroblasts (CAFs), an essential part of the tumor microenvironment (TME), are viewed as potential therapeutic targets. However, their role in tumor mechanisms specific to esophageal cancer remains to be elucidated. This study identified MMP14

Indexed as

Cancer-Associated FibroblastsEsophageal NeoplasmsExosomesImmunotherapyMatrix Metalloproteinase 14Programmed Cell Death 1 ReceptorTumor MicroenvironmentCD8-Positive T-LymphocytesCell Line, TumorHumansMatrix Metalloproteinase 14MMP14 protein, humanPDCD1 protein, humanProgrammed Cell Death 1 ReceptorEsophageal cancerExosomeMMP14+ Cancer-associated fibroblastsPD-1 immunotherapyTsRNA-10522

Identifiers

PMID39377944
PMCPMC11461773

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.