Evidence map›Paper›PMID 39377922›Full record

ReviewNaunyn-Schmiedeberg's archives of pharmacology2025

Advancing against drug-resistant tuberculosis: an extensive review, novel strategies and patent landscape.

Meghana N Patel, Archita J Patel, Manish N Nandpal, Manan A Raval, Ravish J Patel, Amit A Patel, Keshav Raj Paudel, Philip M Hansbro, Sachin Kumar Singh, Gaurav Gupta and 2 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Meghana N PatelRamanbhai Patel College of Pharmacy, Charotar University of Science and Technology, CHARUSAT Campus, At. & Post:-Changa, Tal.:- Petlad, Dist.:- Anand, Gujarat, 388421, India.ORCID 0000-0002-9700-4942
Archita J PatelRamanbhai Patel College of Pharmacy, Charotar University of Science and Technology, CHARUSAT Campus, At. & Post:-Changa, Tal.:- Petlad, Dist.:- Anand, Gujarat, 388421, India.ORCID 0000-0003-2725-8581
Manish N NandpalRamanbhai Patel College of Pharmacy, Charotar University of Science and Technology, CHARUSAT Campus, At. & Post:-Changa, Tal.:- Petlad, Dist.:- Anand, Gujarat, 388421, India.ORCID 0000-0002-6361-4865
Manan A RavalRamanbhai Patel College of Pharmacy, Charotar University of Science and Technology, CHARUSAT Campus, At. & Post:-Changa, Tal.:- Petlad, Dist.:- Anand, Gujarat, 388421, India.ORCID 0000-0002-5823-2264
Ravish J PatelRamanbhai Patel College of Pharmacy, Charotar University of Science and Technology, CHARUSAT Campus, At. & Post:-Changa, Tal.:- Petlad, Dist.:- Anand, Gujarat, 388421, India.ORCID 0000-0002-8442-0349
Amit A PatelRamanbhai Patel College of Pharmacy, Charotar University of Science and Technology, CHARUSAT Campus, At. & Post:-Changa, Tal.:- Petlad, Dist.:- Anand, Gujarat, 388421, India.ORCID 0000-0001-8223-9311
Keshav Raj PaudelCentre for Inflammation, Faculty of Science, School of Life Sciences, Centenary Institute and University of Technology Sydney, Sydney, NSW, 2007, Australia.ORCID 0000-0002-3591-2080
Philip M HansbroCentre for Inflammation, Faculty of Science, School of Life Sciences, Centenary Institute and University of Technology Sydney, Sydney, NSW, 2007, Australia.ORCID 0000-0002-4741-3035
Sachin Kumar SinghSchool of Pharmaceutical Sciences, Lovely Professional University, Phagwara, India.ORCID 0000-0003-3823-6572
Gaurav GuptaCentre for Research Impact & Outcome, Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab, 140401, India.ORCID 0000-0001-7941-0229
Kamal DuaDiscipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Sydney, Australia.ORCID 0000-0002-7507-1159
Samir G PatelRamanbhai Patel College of Pharmacy, Charotar University of Science and Technology, CHARUSAT Campus, At. & Post:-Changa, Tal.:- Petlad, Dist.:- Anand, Gujarat, 388421, India. samirpatel.ph@charusat.ac.in.ORCID 0000-0003-4481-8296

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Drug-resistant tuberculosis (DR-TB) represents a pressing global health issue, leading to heightened morbidity and mortality. Despite extensive research efforts, the escalation of DR-TB cases underscores the urgent need for enhanced prevention, diagnosis, and treatment strategies. This review delves deep into the molecular and genetic origins of different types of DR-TB, highlighting recent breakthroughs in detection and diagnosis, including Rapid Diagnostic Tests like Xpert Ultra, Whole Genome Sequencing, and AI-based tools along with latest viewpoints on diagnosis and treatment of DR-TB utilizing newer and repurposed drug molecules. Special emphasis is given to the pivotal role of novel drugs and discusses updated treatment regimens endorsed by governing bodies, alongside innovative personalized drug-delivery systems such as nano-carriers, along with an analysis of relevant patents in this area. All the compiled information highlights the inherent challenges of current DR-TB treatments, discussing their complexity, potential side effects, and the socioeconomic strain they impose, particularly in under-resourced regions, emphasizing the cost-effective and accessible solutions. By offering insights, this review aims to serve as a compass for researchers, healthcare practitioners, and policymakers, emphasizing the critical need for ongoing R&D to improve treatments and broaden access to crucial TB interventions.

Indexed as

Antitubercular AgentsTuberculosis, Multidrug-ResistantAnimalsHumansMycobacterium tuberculosisPatents as TopicAntitubercular AgentsAI-Based ApproachesDR-TB ManagementDrug-ResistantNovel TechniquesPatent AnalysisTuberculosis

Identifiers

PMID39377922

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.