ArticleVirchows Archiv : an international journal of pathology2024
TTF-1 is a highly sensitive but not fully specific marker for pulmonary and thyroidal cancer: a tissue microarray study evaluating more than 17,000 tumors from 152 different tumor entities.
Article in Virchows Archiv : an international journal of pathology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Molecular-Based Risk Prediction Models for Recurrence After Curative Treatment of Early-Stage Lung Cancer: A Systematic Review and Meta-Analysis.Thoracic cancer · 2026Pooled it
- A case of groove pancreatic carcinoma presenting with rapidly progressive ascending colon stenosis: a rare case report.International journal of surgery case reports · 2026Article
- The presence of thyroid transcription factor 1 (TTF1) in the respiratory stomach of Ancistrus multispinis (Regan, 1912) and the respiratory intestine of the bronze corydoras Corydoras aeneus (Gill).Histochemistry and cell biology · 2026Article
- The TTF-1 and Napsin A Trap: Metastatic Endometrial Carcinoma Masquerading as Lung Primary.International journal of surgical pathology · 2026Article
- When Lymph Nodes Don't Lie: Report of Three Unusual Presentations of Thoracic Tumors.Diagnostics (Basel, Switzerland) · 2026Article
- Article
- International Registry of NKX2-1-Related Disorders: Clinical, Genetic, and Imaging Perspectives.Movement disorders : official journal of the Movement Disorder Society · 2026Observational
- Diagnostic Value of Next-Generation Sequencing (NGS) and Microarray in Characterizing Tumor Origin: A Challenging and Educational Case.The American journal of case reports · 2026Article
- Case report: Primary pulmonary rhabdomyosarcoma exhibiting epithelial morphology and unusual immunophenotype - A significant diagnostic pitfall.Respiratory medicine case reports · 2026Article
- Precision Thyroid Oncology: A Review of Multi-Omics Biomarkers and Spatiotemporal Technologies.International journal of general medicine · 2026Review
- Primary Gastric Adenocarcinoma with Thyroid Transcription Factor-1 Positivity Mimicking Gastric Metastasis from Lung Cancer: A Case Report.Surgical case reports · 2026Article
- Clinicopathology of adenocarcinoma originating from the anal gland with immunohistochemical expressions of GATA3 and TTF-1: a case report and literature review.Frontiers in oncology · 2026Article
- Aberrant TTF-1 expression in metastatic colorectal adenocarcinoma mimicking primary lung cancer: a case report and review of diagnostic pitfalls.Diagnostic pathology · 2025Review
- Rectal metastasis as the initial presentation of primary lung adenocarcinoma with an EGFR L858R mutation: a case report.World journal of surgical oncology · 2025Article
- Unresectable Primary Enteric-Type Thymic Adenocarcinoma Treated With FOLFOX Chemotherapy: A Case Report.Cancer reports (Hoboken, N.J.) · 2025Article
- TTF-1 expression stratifies chemoimmunotherapy benefits in PD-L1-negative lung adenocarcinoma: a real-world biomarker validation.Journal of thoracic disease · 2025Article
- Immunohistochemical TTF-1 and Napsin a Expression in Gastrointestinal Adenocarcinomas-Low Frequency but an Important Pitfall.Diagnostics (Basel, Switzerland) · 2025Article
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Abstract
Thyroid transcription factor 1 (TTF-1) immunohistochemistry (IHC) is routinely used for the distinction of primary pulmonary adenocarcinomas. However, TTF-1 can also occur in other malignancies. A tissue microarray containing 17,772 samples from 152 different tumor types was analyzed. Napsin-A, CK20, SATB2, FABP1, and Villin-1 IHC data were available from previous studies. TTF-1 staining was seen in 82 of 152 tumor categories including thyroidal cancers (19-100%), adenocarcinomas (94%), neuroendocrine tumors (67%) of the lung, small cell neuroendocrine carcinomas (71-80%), mesenchymal tumors (up to 42%), and thymomas (39%). Comparative analysis of TTF-1 and Napsin-A revealed a sensitivity/specificity of 94%/86% (TTF-1), 87%/98% (Napsin-A), and 85%/99.1% (TTF-1 and Napsin-A) for the distinction of pulmonary adenocarcinomas. Combined analysis of TTF-1 and enteric markers revealed a positivity for TTF-1 and at least one enteric marker in 22% of pulmonary adenocarcinomas but also a TTF-1 positivity in 6% of colorectal, 2% of pancreatic, and 3% of gastric adenocarcinomas. TTF-1 is a marker of high sensitivity but insufficient specificity for pulmonary adenocarcinomas. A small fraction of TTF-1-positive gastrointestinal adenocarcinomas represents a pitfall mimicking enteric-type pulmonary adenocarcinoma. Combined analysis of TTF-1 and Napsin-A improves the specificity of pulmonary adenocarcinoma diagnosis.
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