Evidence map›Paper›PMID 39377900›Full record

ArticleJournal of pharmacokinetics and pharmacodynamics2024

Computing optimal drug dosing regarding efficacy and safety: the enhanced OptiDose method in NONMEM.

Freya Bachmann, Gilbert Koch, Robert J Bauer, Britta Steffens, Gabor Szinnai, Marc Pfister, Johannes Schropp

Abstract read
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In one paragraph

Article in Journal of pharmacokinetics and pharmacodynamics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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0cells of the map it votes in
2citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. SCOUT: An Exploratory Approach to Scouting Dose-Relevant Covariates.CPT: pharmacometrics & systems pharmacology · 2026
    Article
  2. Article
4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

7 authors.

Freya BachmannDepartment of Mathematics and Statistics, University of Konstanz, PO Box 195, 78457, Konstanz, Germany. freya.bachmann@uni-konstanz.de.
Gilbert KochPediatric Pharmacology and Pharmacometrics, University of Basel Children's Hospital, Spitalstrasse 33, 4056, Basel, Switzerland.
Robert J BauerICON Clinical Research LLC, Blue Bell, PA, USA.
Britta SteffensPediatric Pharmacology and Pharmacometrics, University of Basel Children's Hospital, Spitalstrasse 33, 4056, Basel, Switzerland.
Gabor SzinnaiPediatric Endocrinology and Diabetology, University of Basel Children's Hospital, Spitalstrasse 33, 4056, Basel, Switzerland.
Marc PfisterPediatric Pharmacology and Pharmacometrics, University of Basel Children's Hospital, Spitalstrasse 33, 4056, Basel, Switzerland.
Johannes SchroppDepartment of Mathematics and Statistics, University of Konstanz, PO Box 195, 78457, Konstanz, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recently, an optimal dosing algorithm (OptiDose) was developed to compute the optimal drug doses for any pharmacometrics model for a given dosing scenario. In the present work, we enhance the OptiDose concept to compute optimal drug dosing with respect to both efficacy and safety targets. Usually, these are not of equal importance, but one is a top priority, that needs to be satisfied, whereas the other is a secondary target and should be achieved as good as possible without failing the top priority target. Mathematically, this leads to state-constrained optimal control problems. In this paper, we elaborate how to set up such problems and transform them into classical unconstrained optimal control problems which can be solved in NONMEM. Three different optimal dosing tasks illustrate the impact of the proposed enhanced OptiDose method.

Indexed as

AlgorithmsComputer SimulationDose-Response Relationship, DrugHumansModels, BiologicalPharmaceutical PreparationsPharmaceutical PreparationsDose optimizationEfficacyOptimal controlOptimal dosingSafetyState constraints

Identifiers

PMID39377900
PMCPMC11579100

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.