Evidence map›Paper›PMID 39377813›Full record

ArticleSkeletal radiology2025

Visual assessment and quantitative analysis of dual-energy CT virtual non-calcium in imaging diagnosis of multiple myeloma.

Linlin Liang, Fangyan Xiao, Luxiao Liang, Chaotian Luo, Fei Peng, Xiaojing Ning, Cheng Tang, Ruchang Chen, Fuling Huang, Peng Peng

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Article in Skeletal radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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10 authors.

Linlin Liang *Department of Radiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, China.
Fangyan Xiao *Department of Radiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, China.
Luxiao LiangDepartment of Radiology, Guangxi International ZhuangYi Hospital, Nanning, China.
Chaotian LuoDepartment of Radiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, China.
Fei PengDepartment of Radiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, China.
Xiaojing NingDepartment of Radiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, China.
Cheng TangDepartment of Radiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, China.
Ruchang ChenDepartment of Radiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, China.
Fuling HuangDepartment of Radiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, China.
Peng PengDepartment of Radiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, China. doublep@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the reliability and diagnostic performance of dual-energy CT virtual non-calcium imaging in diagnosing bone marrow infiltration in multiple myeloma. MATERIALS AND

methodsSeventy-two patients with multiple myeloma and ten controls were recruited. Patients received dual-energy CT and MRI while controls underwent dual-energy CT only, covering the cervical, thoracic, and lumbar spine and the pelvis. Virtual non-calcium images were compared with magnetic resonance images for confirmation and pattern classification. Fleiss Kappa analysis assessed consistency between virtual non-calcium and MRI classifications. Inter-observer agreement for virtual non-calcium and CT attenuation values was evaluated using Bland-Altman analysis. Diagnostic performances across various sites were evaluated using analysis of variance and receiver operating characteristic curve analysis.

resultsDual-energy CT achieved higher consistency in classifying bone marrow infiltration in multiple myeloma than did MRI (kappa = 0.944). In the overall analysis, the mean virtual non-calcium attenuation values in the bone marrow infiltration group (- 28.3 HU; 95% confidence interval (CI), - 32.1, - 24.6) were higher than those in the non-bone marrow infiltration (- 97.5 HU; 95% CI, - 104.7, - 90.3) and control (- 89.1 HU; 95% CI, - 95.1, - 83.1; F = 172.027, P < 0.001) groups. The optimal cutoff values for virtual non-calcium attenuation varied across the overall (- 42.2 HU), cervical spine (- 21.9 HU), thoracic spine (- 42.8 HU), lumbar spine (- 56.9 HU), and pelvis (- 66.3 HU).

conclusionDual-energy CT virtual non-calcium imaging and MRI exhibited good consistency in categorising bone marrow infiltration patterns in multiple myeloma. Different virtual non-calcium attenuation value cutoffs should be used to diagnose bone marrow infiltration in various body regions.

Indexed as

Multiple MyelomaRadiography, Dual-Energy Scanned ProjectionTomography, X-Ray ComputedAdultAgedBone MarrowFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedReproducibility of ResultsSensitivity and SpecificityBone marrowComputed tomographyDual-energyMultiple myelomaVirtual non-calcium

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PMID39377813

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