Evidence map›Paper›PMID 39377802›Full record

ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2024

Single-cell transcriptome analysis of the mouse lungs during the injury and recovery periods after lipopolysaccharide administration.

Hou-Ping Wang, Jian He, Jian-Rong He, Dan-Dan Li, He Huang, Bing Chen

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Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Hou-Ping Wang *Department of Anesthesia, The Second Affiliated Hospital of Chongqing Medical University, No. 74 Linjianglu, Yuzhong District, Chongqing, 400010, China.
Jian He *Department of Spine Surgery, Center of Orthopedics, State Key Laboratory of Trauma and Chemical Poisoning, Daping Hospital, Army Medical University, Third Military Medical University), Chongqing, 400042, China.
Jian-Rong HeDepartment of Anesthesia, The Second Affiliated Hospital of Chongqing Medical University, No. 74 Linjianglu, Yuzhong District, Chongqing, 400010, China.
Dan-Dan LiDepartment of Anesthesia, The Second Affiliated Hospital of Chongqing Medical University, No. 74 Linjianglu, Yuzhong District, Chongqing, 400010, China.
He HuangDepartment of Anesthesia, The Second Affiliated Hospital of Chongqing Medical University, No. 74 Linjianglu, Yuzhong District, Chongqing, 400010, China.
Bing ChenDepartment of Anesthesia, The Second Affiliated Hospital of Chongqing Medical University, No. 74 Linjianglu, Yuzhong District, Chongqing, 400010, China. chenbing@cqmu.edu.cn.

Funding

China Postdoctoral Science Foundation 2021M700629General Hospital of Western Theater Command Research Project 2021-XZYG-B10Kuanren Talents Program of the Second Affiliated Hospital of Chongqing Medical University [2021]24National Natural Science Foundation of China 81700046
6 · The paper itself

Abstract

objectiveThis study sought to investigate the cellular and molecular alterations during the injury and recovery periods of ALI and develop effective treatments for ALI.

methodsPulmonary histology at 1, 3, 6, and 9 days after lipopolysaccharide administration mice were assessed. An unbiased single-cell RNA sequencing was performed in alveoli tissues from injury (day 3) and recovery (day 6) mice after lipopolysaccharide administration. The roles of Fpr2 and Dpp4 in ALI were assessed.

resultsThe most severe lung injury occurred on day 3, followed by recovery entirely on day 9 after lipopolysaccharide administration. The numbers of Il1a

conclusionsOur results offer valuable insights into the cellular and molecular mechanisms underlying its progression and identify Dpp4 as an effective therapeutic target for ALI.

Indexed as

Acute Lung InjuryDipeptidyl Peptidase 4LipopolysaccharidesLungMice, Inbred C57BLSingle-Cell AnalysisAnimalsDipeptidyl-Peptidase IV InhibitorsGene Expression ProfilingMacrophages, AlveolarMaleMiceNeutrophilsReceptors, Formyl PeptideSingle-Cell Gene Expression AnalysisTranscriptomeDipeptidyl Peptidase 4Dipeptidyl-Peptidase IV InhibitorsDpp4 protein, mouseformyl peptide receptor 2, mouseLipopolysaccharidesReceptors, Formyl PeptideAcute lung injuryDPP4InjuryLipopolysaccharideRecoverySingle-cell RNA-seq (scRNA-seq)

Identifiers

PMID39377802

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