Evidence map›Paper›PMID 39377749›Full record

ArticleImmunity, inflammation and disease2024

Inhibition of intestinal inflammation and fibrosis by Scutellaria Baicalensis georgi and Boswellia serrata in human epithelial cells and fibroblasts.

Ilaria Laudadio, Beatrice Leter, Francesca Palone, Salvatore Cucchiara, Claudia Carissimi, Noemi Scafa, Daniela Secci, Roberta Vitali, Laura Stronati

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In one paragraph

Article in Immunity, inflammation and disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. World journal of gastroenterology · 2026
    Review
  2. Review
  3. Article
  4. Article
  5. Effects ofJournal of oral biology and craniofacial research
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ilaria LaudadioDepartment of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena 324, Rome, Italy.ORCID 0000-0002-0990-3201
Beatrice LeterDepartment of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Viale del Policlinico 155, Rome, Italy.
Francesca PaloneLaboratory of Biomedical Technologies, Italian National Agency for New Technologies, Energy and Sustainable Economic Development (ENEA), Via Anguillarese, 301, Santa Maria di Galeria Rome, Italy.
Salvatore CucchiaraDepartment of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Viale del Policlinico 155, Rome, Italy.
Claudia CarissimiDepartment of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena 324, Rome, Italy.
Noemi ScafaDepartment of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena 324, Rome, Italy.
Daniela SecciDepartment of Chemistry and Pharmaceutical Technologies, Sapienza University of Rome, P.le Aldo Moro, Rome, Italy.
Roberta VitaliDepartment of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Viale del Policlinico 155, Rome, Italy.
Laura StronatiDepartment of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena 324, Rome, Italy.ORCID 0000-0001-5222-9497

Funding

This research was funded by Cadigroup Farmaceutici
6 · The paper itself

Abstract

objective and rationaleInflammatory bowel disease, including Crohn's disease and ulcerative colitis, manifests with chronic intestinal inflammation and frequent sequential fibrosis. Current pharmacological therapies may show harmful side effects and are not useful for prevention or resolution of fibrosis. Thus, the use of alternative therapies is emerging as a novel useful approach. Previous results suggest that Scutellaria baicalensis Georgi (SBG) and Boswellia serrata (BS) display anti-inflammatory properties. The aim of this study was to investigate in intestinal epithelial cells and fibroblasts the anti-inflammatory and anti-fibrotic potential of SBG and BS, alone or in combination.

methodsHuman colorectal adenocarcinoma cells (HT29), human intestinal epithelial cells (HIEC6) and human colon fibroblasts (CCD-18Co) were used. Cells were pretreated with SBG and BS and then exposed to pro-inflammatory and pro-fibrotic cytokines.

resultsSBG and BS extracts significantly decreased pro-inflammatory cytokine expression and improved epithelial restitution in HT29 and HIEC6 cells. Besides, fibrotic marker expression, including SNAIL, ACTA2, ZNF281, was strongly reduced. Colon myofibroblasts treated with SBG and BS showed a significant decrease of fibrotic markers as well.

conclusionsSBG and BS extracts significantly reduce inflammation and impair fibrosis in intestinal epithelial cells and colon myofibroblasts. No cooperative effect is observed.

Indexed as

BoswelliaEpithelial CellsFibroblastsFibrosisPlant ExtractsScutellaria baicalensisActinsAnti-Inflammatory AgentsCell LineCytokinesHT29 CellsHumansInflammationInflammatory Bowel DiseasesIntestinal MucosaSnail Family Transcription FactorsACTA2 protein, humanActinsAnti-Inflammatory AgentsCytokinesPlant ExtractsScutellaria baicalensis extractSnail Family Transcription FactorsBoswellia SerratafibrosisIBDinflammationScutellaria baicalensis Georgi

Identifiers

PMID39377749
PMCPMC11460024

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.