Evidence map›Paper›PMID 39377679›Full record

ArticleRadiology2024

Detectability of Hypoattenuating Liver Lesions with Deep Learning CT Reconstruction: A Phantom and Patient Study.

Jinjin Cao, Nayla Mroueh, Nathaniel Mercaldo, Simon Lennartz, Sasiprang Kongboonvijit, Shravya Srinivas Rao, Nisanard Pisuchpen, Vinit Baliyan, Theodore T Pierce, Mark A Anderson and 3 more

Abstract read
In one paragraph

Article in Radiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jinjin Cao *From the Department of Radiology, Division of Abdominal Radiology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, White 270, Boston, MA 02114-2696 (J.C., N. Mroueh, N. Mercaldo, S.L., S.K., S.S.R., N.P., V.B., T.T.P., M.A.A., M.S., A.S.S.B., A.R.K.); Institute for Diagnostic and Interventional Radiology, Faculty of Medicine, University Cologne, University Hospital Cologne, Cologne, Germany (S.L.); and Department of Radiology, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Chulalongkorn University, Bangkok, Thailand (S.K., N.P.).ORCID 0000-0002-2273-7084
Nayla Mroueh *From the Department of Radiology, Division of Abdominal Radiology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, White 270, Boston, MA 02114-2696 (J.C., N. Mroueh, N. Mercaldo, S.L., S.K., S.S.R., N.P., V.B., T.T.P., M.A.A., M.S., A.S.S.B., A.R.K.); Institute for Diagnostic and Interventional Radiology, Faculty of Medicine, University Cologne, University Hospital Cologne, Cologne, Germany (S.L.); and Department of Radiology, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Chulalongkorn University, Bangkok, Thailand (S.K., N.P.).
Nathaniel MercaldoFrom the Department of Radiology, Division of Abdominal Radiology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, White 270, Boston, MA 02114-2696 (J.C., N. Mroueh, N. Mercaldo, S.L., S.K., S.S.R., N.P., V.B., T.T.P., M.A.A., M.S., A.S.S.B., A.R.K.); Institute for Diagnostic and Interventional Radiology, Faculty of Medicine, University Cologne, University Hospital Cologne, Cologne, Germany (S.L.); and Department of Radiology, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Chulalongkorn University, Bangkok, Thailand (S.K., N.P.).ORCID 0000-0003-1658-6598
Simon LennartzFrom the Department of Radiology, Division of Abdominal Radiology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, White 270, Boston, MA 02114-2696 (J.C., N. Mroueh, N. Mercaldo, S.L., S.K., S.S.R., N.P., V.B., T.T.P., M.A.A., M.S., A.S.S.B., A.R.K.); Institute for Diagnostic and Interventional Radiology, Faculty of Medicine, University Cologne, University Hospital Cologne, Cologne, Germany (S.L.); and Department of Radiology, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Chulalongkorn University, Bangkok, Thailand (S.K., N.P.).ORCID 0000-0002-3254-4809
Sasiprang KongboonvijitFrom the Department of Radiology, Division of Abdominal Radiology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, White 270, Boston, MA 02114-2696 (J.C., N. Mroueh, N. Mercaldo, S.L., S.K., S.S.R., N.P., V.B., T.T.P., M.A.A., M.S., A.S.S.B., A.R.K.); Institute for Diagnostic and Interventional Radiology, Faculty of Medicine, University Cologne, University Hospital Cologne, Cologne, Germany (S.L.); and Department of Radiology, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Chulalongkorn University, Bangkok, Thailand (S.K., N.P.).ORCID 0009-0001-3632-1987
Shravya Srinivas RaoFrom the Department of Radiology, Division of Abdominal Radiology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, White 270, Boston, MA 02114-2696 (J.C., N. Mroueh, N. Mercaldo, S.L., S.K., S.S.R., N.P., V.B., T.T.P., M.A.A., M.S., A.S.S.B., A.R.K.); Institute for Diagnostic and Interventional Radiology, Faculty of Medicine, University Cologne, University Hospital Cologne, Cologne, Germany (S.L.); and Department of Radiology, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Chulalongkorn University, Bangkok, Thailand (S.K., N.P.).ORCID 0000-0002-6864-9493
Nisanard PisuchpenFrom the Department of Radiology, Division of Abdominal Radiology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, White 270, Boston, MA 02114-2696 (J.C., N. Mroueh, N. Mercaldo, S.L., S.K., S.S.R., N.P., V.B., T.T.P., M.A.A., M.S., A.S.S.B., A.R.K.); Institute for Diagnostic and Interventional Radiology, Faculty of Medicine, University Cologne, University Hospital Cologne, Cologne, Germany (S.L.); and Department of Radiology, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Chulalongkorn University, Bangkok, Thailand (S.K., N.P.).ORCID 0000-0002-9082-2977
Vinit BaliyanFrom the Department of Radiology, Division of Abdominal Radiology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, White 270, Boston, MA 02114-2696 (J.C., N. Mroueh, N. Mercaldo, S.L., S.K., S.S.R., N.P., V.B., T.T.P., M.A.A., M.S., A.S.S.B., A.R.K.); Institute for Diagnostic and Interventional Radiology, Faculty of Medicine, University Cologne, University Hospital Cologne, Cologne, Germany (S.L.); and Department of Radiology, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Chulalongkorn University, Bangkok, Thailand (S.K., N.P.).
Theodore T PierceFrom the Department of Radiology, Division of Abdominal Radiology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, White 270, Boston, MA 02114-2696 (J.C., N. Mroueh, N. Mercaldo, S.L., S.K., S.S.R., N.P., V.B., T.T.P., M.A.A., M.S., A.S.S.B., A.R.K.); Institute for Diagnostic and Interventional Radiology, Faculty of Medicine, University Cologne, University Hospital Cologne, Cologne, Germany (S.L.); and Department of Radiology, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Chulalongkorn University, Bangkok, Thailand (S.K., N.P.).ORCID 0000-0003-3244-0994
Mark A AndersonFrom the Department of Radiology, Division of Abdominal Radiology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, White 270, Boston, MA 02114-2696 (J.C., N. Mroueh, N. Mercaldo, S.L., S.K., S.S.R., N.P., V.B., T.T.P., M.A.A., M.S., A.S.S.B., A.R.K.); Institute for Diagnostic and Interventional Radiology, Faculty of Medicine, University Cologne, University Hospital Cologne, Cologne, Germany (S.L.); and Department of Radiology, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Chulalongkorn University, Bangkok, Thailand (S.K., N.P.).ORCID 0000-0002-6144-9093
Madeleine SerticFrom the Department of Radiology, Division of Abdominal Radiology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, White 270, Boston, MA 02114-2696 (J.C., N. Mroueh, N. Mercaldo, S.L., S.K., S.S.R., N.P., V.B., T.T.P., M.A.A., M.S., A.S.S.B., A.R.K.); Institute for Diagnostic and Interventional Radiology, Faculty of Medicine, University Cologne, University Hospital Cologne, Cologne, Germany (S.L.); and Department of Radiology, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Chulalongkorn University, Bangkok, Thailand (S.K., N.P.).ORCID 0000-0002-8464-7754
Anuradha S Shenoy-BhangleFrom the Department of Radiology, Division of Abdominal Radiology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, White 270, Boston, MA 02114-2696 (J.C., N. Mroueh, N. Mercaldo, S.L., S.K., S.S.R., N.P., V.B., T.T.P., M.A.A., M.S., A.S.S.B., A.R.K.); Institute for Diagnostic and Interventional Radiology, Faculty of Medicine, University Cologne, University Hospital Cologne, Cologne, Germany (S.L.); and Department of Radiology, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Chulalongkorn University, Bangkok, Thailand (S.K., N.P.).ORCID 0000-0001-8957-6548
Avinash R KambadakoneFrom the Department of Radiology, Division of Abdominal Radiology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, White 270, Boston, MA 02114-2696 (J.C., N. Mroueh, N. Mercaldo, S.L., S.K., S.S.R., N.P., V.B., T.T.P., M.A.A., M.S., A.S.S.B., A.R.K.); Institute for Diagnostic and Interventional Radiology, Faculty of Medicine, University Cologne, University Hospital Cologne, Cologne, Germany (S.L.); and Department of Radiology, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Chulalongkorn University, Bangkok, Thailand (S.K., N.P.).ORCID 0000-0001-6714-9190

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background CT deep learning image reconstruction (DLIR) improves image quality by reducing noise compared with adaptive statistical iterative reconstruction-V (ASIR-V). However, objective assessment of low-contrast lesion detectability is lacking. Purpose To investigate low-contrast detectability of hypoattenuating liver lesions on CT scans reconstructed with DLIR compared with CT scans reconstructed with ASIR-V in a patient and a phantom study. Materials and Methods This single-center retrospective study included patients undergoing portal venous phase abdominal CT between February and May 2021 and a low-contrast-resolution phantom scanned with the same protocol. Four reconstructions (ASIR-V at 40% strength [ASIR-V 40] and DLIR at three strengths) were generated. Five radiologists qualitatively assessed the images using the five-point Likert scale for image quality, lesion diagnostic confidence, conspicuity, and small lesion (≤1 cm) visibility. Up to two key lesions per patient, confirmed at histopathologic testing or at prior or follow-up imaging studies, were included. Lesion-to-background contrast-to-noise ratio was calculated. Interreader variability was analyzed. Intergroup qualitative and quantitative metrics were compared between DLIR and ASIR-V 40 using proportional odds logistic regression models. Results Eighty-six liver lesions (mean size, 15 mm ± 9.5 [SD]) in 50 patients (median age, 62 years [IQR, 57-73 years]; 27 [54%] female patients) were included. Differences were not detected for various qualitative low-contrast detectability metrics between ASIR-V 40 and DLIR (

Indexed as

Deep LearningLiver NeoplasmsPhantoms, ImagingRadiographic Image Interpretation, Computer-AssistedTomography, X-Ray ComputedAgedFemaleHumansLiverMaleMiddle AgedRetrospective Studies

Identifiers

PMID39377679
PMCPMC11535864

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