Evidence map›Paper›PMID 39377387›Full record

ArticleCurrent drug delivery2025

Multi-Stimuli-Responsive Biocompatible Magnetic Nanocarrier as Drug Delivery System to MCF-7 Breast Cancer Cells.

Sedigheh Ehsanimehr, Kimya Badr, Wim Dehaen, Vahid Shafiei Irannejad, Peyman Najafi Moghadam

Abstract read
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In one paragraph

Article in Current drug delivery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Stimuli-responsive bioengineered platforms for precision cancer therapy.Frontiers in bioengineering and biotechnology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sedigheh EhsanimehrDepartment of Organic Chemistry, Faculty of Chemistry, Urmia University, Urmia 57153-165, Iran.
Kimya BadrFaculty of Pharmacy, Cyprus International University, Nicosia, 99258, Northern Cyprus via Mersin 10, Turkey.
Wim DehaenDepartment of Chemistry, Faculty of Science, Kuleuven University, 3001 Leuven, Belgium.
Vahid Shafiei IrannejadCellular and Molecular Research Center, Cellular and Molecular Medicine Institute, Urmia University of Medical Sciences, Urmia, Iran.
Peyman Najafi MoghadamDepartment of Organic Chemistry, Faculty of Chemistry, Urmia University, Urmia 57153-165, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe last strategy in targeted drug delivery systems is to deliver the anticancer drug to the tumor tissue to increase its therapeutic effect and minimize its undesirable side effects. In line with this goal in this research, the redox/pH-responsive disulfide magnetic nanocarriers based on PF127-NH

methodsWe effectively surrounded Fe

resultsThe LCMNPs-SS nanocarrier exhibited excellent properties for controlled release, with a well-defined release rate, a controllable level by an external magnet, and adjusting by DLdithiothreitol concentration. The LCMNPs-SS nanocarrier could also break apart when exposed to an oxidant or a change in pH. This meant that the drug release could be fine-tuned in response to temperature, pH, or more than one stimulus.

conclusionThese drug-carrying systems are valuable in reducing the dose of doxorubicin. High internalization of the synthesized LCMNPs-SS caused sped cellular uptake.

Indexed as

Antineoplastic AgentsNanoparticle Drug Delivery SystemBreast NeoplasmsDelayed-Action PreparationsDoxorubicinDrug CarriersDrug LiberationFemaleFerric CompoundsHumansMagnetite NanoparticlesMCF-7 CellsAntineoplastic AgentsDelayed-Action PreparationsDoxorubicinDrug CarriersFerric Compoundsferric oxideMagnetite NanoparticlesNanoparticle Drug Delivery Systemanti-cancerDL-dithiothreitolLCMNPs-SS smart nanocarrier.magnetic nanocarrierpluronic F-127Targeted drug delivery

Identifiers

PMID39377387

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.