Evidence map›Paper›PMID 39377376›Full record

ArticleCurrent molecular medicine2025

Contribution of the Activated mTOR-STAT3 Pathway to the Pathogenesis of Focal Cortical Dysplasia Type IIIa in Pediatric Patients through Astrocyte Proliferation Mediation.

Jiangya Wang, Jiang Wu, Yang Li, Yuanyuan Lv, Xinying Zhang, Lin Kang

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Article in Current molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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1 citing paper in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Jiangya WangDepartment of Pediatric, Hebei General Hospital, Shijiazhuang, 050000, China.
Jiang WuDepartment of Neurosurgery, Hebei General Hospital, Shijiazhuang, 050000, China.
Yang LiDepartment of Pediatric, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050000, China.
Yuanyuan LvDepartment of Pediatrics, Baoding First Central Hospital, Baoding, 071400, China.
Xinying ZhangDepartment of Pediatric, Hebei General Hospital, Shijiazhuang, 050000, China.
Lin KangDepartment of Pathology, Hebei General Hospital, Shijiazhuang 050000, China.

Funding

medical science research topic in Hebei Province 20241318
6 · The paper itself

Abstract

objectiveThe aim of this study was to detect the association between the mTOR-STAT3 pathway and focal cortical dysplasia type IIIa (FCD IIIa) in children.

methodsA retrospective review was conducted based on 26 pediatric patients diagnosed with FCD IIIa who underwent surgical intervention. These patients were selected from a cohort of 157 individuals presenting with temporal lobe epilepsy. For comparative analysis, a control group consisting of 5 children who underwent intracranial decompression was established. Immunohistochemistry, immunofluorescence, and western blot techniques were used to assess the expression levels of mTOR, P-mTOR, P-70s6k, STAT3, P-STAT3, and GFAP in brain tissue specimens obtained from the two groups.

resultsThe mTOR-STAT3 pathway exhibited activation in the FCD IIIa group (all p < 0.01). Additionally, immunofluorescence analysis revealed that cells positive for PSTAT3 were identified as astrocytes. Moreover, within the FCD IIIa group, there was a marked elevation in the expression of the mTOR-STAT3 pathway in the hippocampus compared to the brain cortex tissue.

conclusionThe mTOR-STAT3 pathway was demonstrated to be substantially associated with FCD IIIa in pediatric patients. The activation of the mTOR-STAT3 signaling pathway may contribute to the pathogenesis of FCD IIIa in pediatric patients by modulating the proliferation of astrocytes.

Indexed as

AstrocytesMalformations of Cortical DevelopmentMalformations of Cortical Development, Group ISignal TransductionSTAT3 Transcription FactorTOR Serine-Threonine KinasesAdolescentCell ProliferationChildChild, PreschoolEpilepsyFemaleFocal Cortical DysplasiaHumansInfantMaleMTOR protein, humanSTAT3 protein, humanSTAT3 Transcription FactorTOR Serine-Threonine KinasesAstrocytechildrenfocal cortical dysplasia IIIaGFAPhippocampusmTOR-STAT3 pathway.

Identifiers

PMID39377376

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