Evidence map›Paper›PMID 39377064›Full record

ArticleMolecular therapy. Nucleic acids2024

Selection of DNA aptamers that prevent the fibrillization of α-synuclein protein in cellular and mouse models.

Erin M McConnell, Dennis Chan, Katelyn Ventura, Joshua P Callahan, Kathryn Harris, Vernon H Hunt, Spencer Boisjoli, Daniel Knight, Evan T Monk, Matthew R Holahan and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy. Nucleic acids, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Erin M McConnellDepartment of Chemistry, Carleton University, Ottawa, ON K1S 5B6, Canada.
Dennis ChanDepartment of Neuroscience, Carleton University, Ottawa, ON K1S 5B6, Canada.
Katelyn VenturaDepartment of Neuroscience, Carleton University, Ottawa, ON K1S 5B6, Canada.
Joshua P CallahanDepartment of Chemistry, Carleton University, Ottawa, ON K1S 5B6, Canada.
Kathryn HarrisDepartment of Neuroscience, Carleton University, Ottawa, ON K1S 5B6, Canada.
Vernon H HuntDepartment of Chemistry, Carleton University, Ottawa, ON K1S 5B6, Canada.
Spencer BoisjoliDepartment of Chemistry, Carleton University, Ottawa, ON K1S 5B6, Canada.
Daniel KnightDepartment of Chemistry, Carleton University, Ottawa, ON K1S 5B6, Canada.
Evan T MonkDepartment of Chemistry, Carleton University, Ottawa, ON K1S 5B6, Canada.
Matthew R HolahanDepartment of Neuroscience, Carleton University, Ottawa, ON K1S 5B6, Canada.
Maria C DeRosaDepartment of Chemistry, Carleton University, Ottawa, ON K1S 5B6, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A neuropathological hallmark of Parkinson's disease (PD) is the aggregation and spreading of misfolded α-synuclein (αSyn) protein. In this study, a selection method was developed to identify aptamers that showed affinity for monomeric αSyn and inhibition of αSyn aggregation. Aptamer

Indexed as

aptamerfibrillizationinhibitorMT: Oligonucleotides: Therapies and ApplicationsParkinson’s diseaseSELEXSH-SY5Y cellsα-synuclein

Identifiers

PMID39377064
PMCPMC11456556

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.