Evidence map›Paper›PMID 39377016›Full record

ArticleJournal of circulating biomarkers

A novel liquid biopsy assay for detection of

Giuseppe Di Caro, Ernest T Lam, David Bourdon, Martin Blankfard, Nilesh Dharajiya, Megan Slade, Emily Williams, Dong Zhang, Rick Wenstrup, Lee Schwartzberg

Abstract read
In one paragraph

Article in Journal of circulating biomarkers. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Giuseppe Di CaroEpic Sciences, San Diego, California - USA.
Ernest T LamEpic Sciences, San Diego, California - USA.
David BourdonEpic Sciences, San Diego, California - USA.
Martin BlankfardEpic Sciences, San Diego, California - USA.
Nilesh DharajiyaEpic Sciences, San Diego, California - USA.
Megan SladeEpic Sciences, San Diego, California - USA.
Emily WilliamsEpic Sciences, San Diego, California - USA.
Dong ZhangEpic Sciences, San Diego, California - USA.
Rick WenstrupEpic Sciences, San Diego, California - USA.
Lee SchwartzbergRenown Health-Pennington Cancer Institute, Reno, Nevada - USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Circulating tumor cell (CTC)-based Patients and methods: Peripheral blood was collected in Streck tubes and centrifugation was used to remove plasma and red blood cells. The remaining nucleated cells were deposited on glass slides, immunofluorescent-stained with proprietary antibodies, scanned by a high-definition digital scanner, and analyzed by a proprietary algorithm. In addition, single-cell genomics was performed on selected CTC. Analytical validation was performed using white blood cells from healthy donors and breast cancer cell lines with known levels of Results: Epic's Conclusions: The CTC

Indexed as

Analytical validationBreast cancerCirculating tumor cellsEpic CTC platformHER2Liquid biopsy

Identifiers

PMID39377016
PMCPMC11456801

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.