Evidence map›Paper›PMID 39376999›Full record

SynthesisFrontiers in public health2024

Air pollutants and ovarian reserve: a systematic review of the evidence.

Roberta Zupo, Fabio Castellana, Tim S Nawrot, Luisa Lampignano, Ilaria Bortone, Ferdinando Murgia, Gianluca Campobasso, Agnieskza Gruszecka Kosowska, Orazio Valerio Giannico, Rodolfo Sardone

Abstract readSystematic Review
In one paragraph

Synthesis in Frontiers in public health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. FIGO committee opinion: Environmental drivers of gynecologic and reproductive health.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Roberta ZupoDepartment of Interdisciplinary Medicine (DIM), University of Bari Aldo Moro, Piazza Giulio Cesare, Bari, Italy.
Fabio CastellanaDepartment of Interdisciplinary Medicine (DIM), University of Bari Aldo Moro, Piazza Giulio Cesare, Bari, Italy.
Tim S NawrotCentre for Environmental Sciences, Hasselt University, Diepenbeek, Belgium.
Luisa LampignanoLocal Healthcare Authority of Bari, ASL Bari, Bari, Italy.
Ilaria BortoneDepartment of Translational Biomedicine and Neuroscience "DiBraiN", University of Bari "Aldo Moro", Bari, Italy.
Ferdinando MurgiaDepartment of Obstetrics and Gynecology, "Miulli" General Hospital, Bari, Italy.
Gianluca CampobassoObstetrics and Gynecology Unit, Vito Fazzi Hospital, Lecce, Italy.
Agnieskza Gruszecka KosowskaDepartment of Environmental Protection, Faculty of Geology, Geophysics and Environmental Protection, AGH University of Krakow, Al. Mickiewicza, Krakow, Poland.
Orazio Valerio GiannicoUnit of Statistics and Epidemiology, Local Health Authority of Taranto, Taranto, Italy.
Rodolfo SardoneUnit of Statistics and Epidemiology, Local Health Authority of Taranto, Taranto, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Growing evidence indicates an association between ambient air pollution and decreased human reproductive potential. This study aims to systematically review the association between air pollutants and female ovarian reserve. Methods: The literature was searched in six electronic databases through June 2024. Screening the 136 articles retrieved for inclusion criteria resulted in the selection of 15 human observational studies that evaluated the effect of environmental pollutants on ovarian reserve markers. The study protocol was registered on the International Prospective Register of Systematic Reviews (PROSPERO, registration code: CRD42023474218). Results: The study design of the selected studies was found to be cross-sectional (2 of 15), retrospective cohort (10 of 15), prospective cohort (2 of 15), and case-control (1 of 15). The study population was distributed as follows: Asians (53%, eight studies), Americans (33%, five studies), and Europeans (14%, two studies). The main findings showed a higher body of evidence for the environmental pollutants PM2.5, PM10, and NO Conclusion: The data suggest that increased exposure to air pollutants seems to be associated with reduced ovarian reserve, with the most substantial evidence for pollutants such as PM2.5, PM10, and NO

Indexed as

Air PollutantsOvarian ReserveAir PollutionEnvironmental ExposureFemaleHumansAir Pollutantsair pollutantsfertilityfine particulate matterovarian reservesystematic review

Identifiers

PMID39376999
PMCPMC11457886

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.