ArticleCureus2024
Cone-Beam Computed Tomography-Guided Online Adaptive Radiotherapy: Promising Results for Bladder Cancer Case.
Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Cone beam computed tomography guided online adaptive radiotherapy for cervical Cancer: Two-year single-Centre implementation and clinical experience.Technical innovations & patient support in radiation oncology · 2026Article
- The role of cone beam CT in personalization of bladder cancer radiotherapy.Radiological physics and technology · 2026Article
- Online adaptive radiation therapy for muscle-invasive bladder cancer: short-course and high-precision definitive treatment for elderly or medically fragile patients.Japanese journal of radiology · 2026Article
- Reduction of the planning target volume with daily online adaptive radiotherapy in bladder cancer.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2025Article
- Customizable Lyophilized Agent for Radiotherapy Imaging and TherapY (CLARITY).Journal of functional biomaterials · 2024Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bladder radiotherapy is challenging due to daily anatomical variations and unpredictable bladder filling, particularly affecting tumors in the cranial part. Conventional radiotherapy requires large planning target volume margins to manage these uncertainties, but this can expose healthy tissue to high radiation doses, increasing the risk of acute and late toxicity. Our aim was to study the potential to limit high-dose exposure to healthy tissue by comparing daily online adaptive radiotherapy (oART) with conventional, non-adaptive radiotherapy (non-ART). The comparison was performed on a bladder cancer patient treated with a simultaneous integrated boost while having a challenging tumor location in the cranial part of the bladder. Liquid fiducial markers aided during the localization of the tumor bed to deliver this focal boost. The dose distribution of oART fractions performed in the clinic was compared with simulated non-ART fractions on the post-treatment cone-beam computed tomography (CBCT). The results showed that while maintaining target coverage of the bladder and gross tumor volume in 100% of the fractions for both workflows, the high dose exposure to organs-at-risk was lower for oART. The small bowel received statistically significantly (p ≤ 0.05) less dose with oART compared to non-ART, with a median volume difference of 20 cm
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Registered trials
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