ArticleCureus2024
A Cross-Sectional Study of the A1 Phenotype in the Colombian Caribbean: A Shadow Behind Pulmonary Embolism.
Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
10 authors.
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Abstract
introductionVenous thromboembolic disease (VTE) is an episodic condition of multifactorial origin, commonly manifesting as deep vein thrombosis (DVT) and pulmonary embolism (PE). VTE is a major cause of morbidity and mortality. As an acute condition, it has the potential for recurrence and is associated with major consequences; this disease poses significant challenges to the healthcare system. VTE is a widespread concern in developed and developing countries; therefore, it is not limited to specific regions or populations.
objectivesTo evaluate the risk factors associated with unprovoked PE in patients in a hospital center in Sincelejo, Colombia.
methodsThis is an observational, analytical cross-sectional study utilizing retrospective data. From 2010 to 2023, we reviewed 126 medical records of patients who experienced their first unprovoked VTE events and met the inclusion criteria. We performed data analysis using R software version 3.5.1.
resultsOf the patients, 36.5% (n = 46) were women; 63.5% (n = 80) were men, with a mean age of 62.22 years (SD = 10.62). About 53% of women presented with PE, compared to 47% of men. The coagulation factor VIII acted as a PE risk factor (p = 0.098). The best model to predict PE development obtained an Akaike information criterion (AIC) of 176.67, indicating that the A1 positive phenotype is the risk factor with the highest prediction for PE occurrence.
conclusionsHigh levels of coagulation factor VIII and an A1-positive phenotype are risk factors that may increase PE development. These findings suggest the need for preventive strategies in this risk setting to reduce the incidence and recurrence of PE.
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