Evidence map›Paper›PMID 39376629›Full record

ArticleFrontiers in cell and developmental biology2024

FGF2 promotes the expansion of parietal mesothelial progenitor pools and inhibits BMP4-mediated smooth muscle cell differentiation.

Youngmin Hwang, Yuko Shimamura, Junichi Tanaka, Akihiro Miura, Anri Sawada, Hemanta Sarmah, Dai Shimizu, Yuri Kondo, Hyeonjeong Lee, Francesca Martini and 4 more

Abstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Stem Cells in Aging and Anti-Aging.Stem cell reviews and reports · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Youngmin HwangColumbia Center for Human Development (CCHD), Columbia University Irving Medical Center, New York, NY, United States.
Yuko ShimamuraColumbia Center for Human Development (CCHD), Columbia University Irving Medical Center, New York, NY, United States.
Junichi TanakaColumbia Center for Human Development (CCHD), Columbia University Irving Medical Center, New York, NY, United States.
Akihiro MiuraColumbia Center for Human Development (CCHD), Columbia University Irving Medical Center, New York, NY, United States.
Anri SawadaColumbia Center for Human Development (CCHD), Columbia University Irving Medical Center, New York, NY, United States.
Hemanta SarmahColumbia Center for Human Development (CCHD), Columbia University Irving Medical Center, New York, NY, United States.
Dai ShimizuColumbia Center for Human Development (CCHD), Columbia University Irving Medical Center, New York, NY, United States.
Yuri KondoColumbia Center for Human Development (CCHD), Columbia University Irving Medical Center, New York, NY, United States.
Hyeonjeong LeeColumbia Center for Human Development (CCHD), Columbia University Irving Medical Center, New York, NY, United States.
Francesca MartiniColumbia Center for Human Development (CCHD), Columbia University Irving Medical Center, New York, NY, United States.
Zurab NinishColumbia Center for Human Development (CCHD), Columbia University Irving Medical Center, New York, NY, United States.
Kelley S YanColumbia Center for Human Development (CCHD), Columbia University Irving Medical Center, New York, NY, United States.
Kazuhiko YamadaDepartment of Surgery, School of Medicine, Johns Hopkins Medicine, Baltimore, MD, United States.
Munemasa MoriColumbia Center for Human Development (CCHD), Columbia University Irving Medical Center, New York, NY, United States.

Funding

Directing Cell Fate Along the Intestinal Enteroendocrine LineageDP2DK128801 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI YAN, KELLEY · 2020 to 2020
$2.4M
Intestinal Stem Cell Function During Aging and Tumor InitiationR01AG067014 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI YAN, KELLEY · 2020 to 2024
$2.3M
Regulatory Mechanisms of Cell Competition in Lung RegenerationR01HL148223 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MORI, MUNEMASA · 2019 to 2022
$2.1M
Leica Stellaris 8 Confocal MicroscopeS10OD032447 · OD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SNOECK, HANS-WILLEM E · 2022 to 2022
$652k
NHLBI NIH HHS R01 HL148223NIA NIH HHS R01 AG067014NIDDK NIH HHS DP2 DK128801NIH HHS S10 OD032447
6 · The paper itself

Abstract

Mesothelial cells, in the outermost layer of internal organs, are essential for both organ development and homeostasis. Although the parietal mesothelial cell is the primary origin of mesothelioma that may highjack developmental signaling, the signaling pathways that orchestrate developing parietal mesothelial progenitor cell (MPC) behaviors, such as MPC pool expansion, maturation, and differentiation, are poorly understood. To address it, we established a robust protocol for culturing WT1

Indexed as

BMP4differentiationFGF2maturationparietal mesothelial cell self-renewalPDGFwnt

Identifiers

PMID39376629
PMCPMC11456698

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.