Evidence map›Paper›PMID 39376521›Full record

ArticleRSC advances2024

Multimodal antibacterial potency of newly designed and synthesized Schiff's/Mannich based coumarin derivatives: potential inhibitors of bacterial DNA gyrase and biofilm production.

Kakarla Pakeeraiah, Pragyan Paramita Swain, Alaka Sahoo, Preetesh Kumar Panda, Monalisa Mahapatra, Suvadeep Mal, Rajesh Kumar Sahoo, Pratap Kumar Sahu, Sudhir Kumar Paidesetty

Abstract read
In one paragraph

Article in RSC advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kakarla PakeeraiahMedicinal Chemistry Research Laboratory, School of Pharmaceutical Sciences, Siksha 'O' Anusandhan Deemed to be University Bhubaneswar 751003 Odisha India psudhirkumar@soa.ac.in.ORCID https://orcid.org/0000-0003-4356-2428
Pragyan Paramita SwainCentre for Biotechnology, School of Pharmaceutical Sciences, Siksha 'O' Anusandhan Deemed to be University Bhubaneswar 751003 Odisha India.ORCID https://orcid.org/0000-0002-1456-2501
Alaka SahooMedicinal Chemistry Research Laboratory, School of Pharmaceutical Sciences, Siksha 'O' Anusandhan Deemed to be University Bhubaneswar 751003 Odisha India psudhirkumar@soa.ac.in.ORCID https://orcid.org/0000-0002-6743-3885
Preetesh Kumar PandaMedicinal Chemistry Research Laboratory, School of Pharmaceutical Sciences, Siksha 'O' Anusandhan Deemed to be University Bhubaneswar 751003 Odisha India psudhirkumar@soa.ac.in.ORCID https://orcid.org/0009-0002-1801-7452
Monalisa MahapatraMedicinal Chemistry Research Laboratory, School of Pharmaceutical Sciences, Siksha 'O' Anusandhan Deemed to be University Bhubaneswar 751003 Odisha India psudhirkumar@soa.ac.in.ORCID https://orcid.org/0000-0002-4974-0662
Suvadeep MalMedicinal Chemistry Research Laboratory, School of Pharmaceutical Sciences, Siksha 'O' Anusandhan Deemed to be University Bhubaneswar 751003 Odisha India psudhirkumar@soa.ac.in.ORCID https://orcid.org/0000-0003-0394-6726
Rajesh Kumar SahooCentre for Biotechnology, School of Pharmaceutical Sciences, Siksha 'O' Anusandhan Deemed to be University Bhubaneswar 751003 Odisha India.ORCID https://orcid.org/0000-0002-4491-4168
Pratap Kumar SahuDepartment of Pharmacology, School of Pharmaceutical Sciences, Siksha 'O' Anusandhan Deemed to be University Bhubaneswar 751003 Odisha India pratapsahu@soa.ac.in.ORCID https://orcid.org/0000-0002-8805-8682
Sudhir Kumar PaidesettyMedicinal Chemistry Research Laboratory, School of Pharmaceutical Sciences, Siksha 'O' Anusandhan Deemed to be University Bhubaneswar 751003 Odisha India psudhirkumar@soa.ac.in.ORCID https://orcid.org/0000-0003-1210-2293

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The briskened urge to develop potential antibacterial candidates against multidrug-resistant pathogens has motivated the present research study. Herein, newly synthesized coumarin derivatives with azomethine and amino-methylated as the functional groups have been focused on their antibacterial efficacy. The study proposed two distinct series: 3-acetyl substituted coumarin derivatives, followed by the Schiff base approach (5a-5i), and formaldehyde-secondary cyclic amine-based derivatives (7a-7g), using the Mannich base approach, further the compounds have been confirmed through various spectral studies. Further, target-specific binding affinity has been affirmed

Identifiers

PMID39376521
PMCPMC11457008

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.