ArticleEuropean psychiatry : the journal of the Association of European Psychiatrists2024
Early-life adversity predicting the incidence of multisite chronic pain in the general population.
Article in European psychiatry : the journal of the Association of European Psychiatrists, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- The Intraplantar CFA Inflammatory Pain Model Incompletely Captures Pain Comorbidities Across Sexes.Journal of neuroscience research · 2026Article
- Effects of early life adversity on socially learned analgesia and empathy in virtual reality.NPJ digital medicine · 2026Article
- The association between age at menarche and subsequent risk of chronic pain.Frontiers in global women's health · 2026Review
- Parental upheaval experienced in childhood and its effect on pain-related cognitions across the lifespan: an exploratory investigation.Frontiers in pain research (Lausanne, Switzerland) · 2026Article
- Effects of childhood adversity on socially learned placebo analgesia in virtual reality: A cross-sectional study.medRxiv : the preprint server for health sciences · 2025Article
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Authors and funding
11 authors.
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Abstract
introductionAdverse childhood events (ACEs) have been linked to widespread chronic pain (CP) in various cross-sectional studies, mainly in clinical populations. However, the independent role of different ACEs on the development of different types of CP remains elusive. Accordingly, we aimed to prospectively assess the associations between specific types of ACEs with the development of multisite CP in a large population-based cohort.
methodsData stemmed from the three first follow-up evaluations of CoLaus|PsyCoLaus, a prospective population-based cohort study of initially 6734 participants (age range: 35-75 years). The present sample included 1537 participants with 2161 analyzable intervals (49.7% men, mean age 57.3 years). Diagnostic criteria for ACEs were elicited using semi-structured interviews and CP was assessed by self-rating questionnaires. Multinomial logistic regressions with generalized estimating equations method analyzed the relationship between the different ACEs measured in the beginning of the interval and the risk of developing multisite CP during the follow-up. Sensitivity analyses were performed to assess the predictive value of ACEs on multisite CP with neuropathic features.
resultsParticipants with a history of parental divorce or separation had an increased risk of developing multisite CP at during follow-up in comparison to those without (RR1.98; 95% CI 1.13-3.47). A strong association was highlighted between parental divorce or separation and the risk of subsequent CP with neuropathic characteristics (RR 4.21, 95% CI 1.45-12.18).
conclusionThese results highlight the importance of psychotherapeutic management of people experiencing parental separation to prevent CP in the future.
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