Evidence map›Paper›PMID 39375561›Full record

ReviewNature reviews. Genetics2025

A call to action to scale up research and clinical genomic data sharing.

Zornitza Stark, David Glazer, Oliver Hofmann, Augusto Rendon, Christian R Marshall, Geoffrey S Ginsburg, Chris Lunt, Naomi Allen, Mark Effingham, Jillian Hastings Ward and 7 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed.

  1. Review
  2. Genomic Data Governance Challenges Between Research and Clinical Care: A Scoping Review.Health expectations : an international journal of public participation in health care and health policy · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Collaborative Genomics for Dystonia in Central and Eastern Europe: Successes Achieved, New Frontiers Ahead.Movement disorders : official journal of the Movement Disorder Society · 2026
    Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Zornitza StarkAustralian Genomics, Melbourne, Victoria, Australia. zornitza.stark@vcgs.org.au.ORCID http://orcid.org/0000-0001-8640-1371
David GlazerVerily Life Sciences, South San Francisco, CA, USA. dglazer@verily.com.ORCID http://orcid.org/0000-0002-6407-8646
Oliver HofmannAustralian Genomics, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0002-7738-1513
Augusto RendonGenomics England, London, UK.ORCID http://orcid.org/0000-0001-8994-0039
Christian R MarshallDivision of Genome Diagnostics, Pediatric Laboratory Medicine Department, The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0002-4003-7671
Geoffrey S GinsburgAll of Us Research Program, National Institutes of Health, Bethesda, MD, USA.
Chris LuntAll of Us Research Program, National Institutes of Health, Bethesda, MD, USA.
Naomi AllenNuffield Department of Population Health, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0003-1938-5038
Mark EffinghamUK Biobank, Stockport, UK.
Jillian Hastings WardParticipant Panel, Genomics England, London, UK.ORCID http://orcid.org/0000-0001-5146-5498
Sue L HillNational Health Service England, London, UK.
Raghib AliOur Future Health, Manchester, UK.
Peter GoodhandGlobal Alliance for Genomics and Health, Toronto, Ontario, Canada.
Angela PageGlobal Alliance for Genomics and Health, Toronto, Ontario, Canada.
Heidi L RehmGlobal Alliance for Genomics and Health, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0002-6025-0015
Kathryn N NorthAustralian Genomics, Melbourne, Victoria, Australia.
Richard H ScottGenomics England, London, UK.ORCID http://orcid.org/0000-0002-9113-2978

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genomic data from millions of individuals have been generated worldwide to drive discovery and clinical impact in precision medicine. Lowering the barriers to using these data collectively is needed to equitably realize the benefits of the diversity and scale of population data. We examine the current landscape of global genomic data sharing, including the evolution of data sharing models from data aggregation through to data visiting, and for certain use cases, cross-cohort analysis using federated approaches across multiple environments. We highlight emerging examples of best practice relating to participant, patient and community engagement; evolution of technical standards, tools and infrastructure; and impact of research and health-care policy. We outline 12 actions we can all take together to scale up efforts to enable safe global data sharing and move beyond projects demonstrating feasibility to routinely cross-analysing research and clinical data sets, optimizing benefit.

Indexed as

Biomedical ResearchGenomicsInformation DisseminationHumansPrecision Medicine

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.