Evidence map›Paper›PMID 39375504›Full record

Observational studyPediatric research2025

Clinical characteristics and outcomes of COVID-19 in pediatric patients with rheumatic diseases.

Yating Wang, Shu Su, Mingsheng Ma, Ruohang Weng, Zhiyong Zhang, Dawei Liu, Xin Yan, Junjun Wang, Yajun Wang, Wei Zhang and 28 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Pediatric research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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3 · Its place in the literature

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1 citing paper in PubMed.

  1. Article
4 · The record

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5 · Who and what money

Authors and funding

38 authors.

Yating Wang *Department of Rheumatology and Immunology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders. Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing, China.
Shu Su *Department of Epidemiology and Biostatistics, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Mingsheng Ma *Department of Pediatrics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
Ruohang Weng *Rheumatology & Immunology Department of Shenzhen Children's Hospital, Shenzhen, China.
Zhiyong ZhangDepartment of Rheumatology and Immunology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders. Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing, China.
Dawei LiuDepartment of Rheumatology and Immunology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders. Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing, China.
Xin YanDepartment of Rheumatology and Immunology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders. Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing, China.
Junjun WangDepartment of Rheumatology and Immunology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders. Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing, China.
Yajun WangDepartment of Rheumatology and Immunology, The First People's Hospital of Yunnan Province, Kunming, China.
Wei ZhangPediatric Immunology and Rheumatology Department, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 611731, China.
Sirui YangDepartment of pediatric rheumatology, immunology, and allergy, The First Hospital of Jilin University, Changchun, Jilin, China.
Hongxia ZhangDepartment of Pediatric Nephrology, Rheumatology and Immunology, Children's Hospital Affiliated to Shandong University, Jinan Children's Hospital, Jinan, Shandong, China.
Dongmei ZhaoDepartment of Rheumatology and Immunology, Children's Hospital of Urumqi, No.1 Jiankang Rd., TianShan Distinct, Urumqi, China.
Meiping LuDepartment of Rheumatology Immunology and Allergy, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
Xiaoqing LiDepartment of Rheumatology and Immunology, Xi'an Children's Hospital, Xi'an, 710068, China.
Jia ZhuDepartment of Rheumatology and Immunology, The Affiliated Children's Hospital, Capital Institute of Pediatrics, 2 Yabao Road, Chaoyang District, 100020, Beijing, China.
Weixi ZhangDepartment of Pediatric Allergy and Immunology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027, China.
Haiguo YuDepartment of Rheumatology and Immunology, Children's Hospital of Nanjing Medical University No. 72 Guangzhou Road, Nanjing, 210008, Jiangsu, China.
Dongfeng ZhangDepartment of Pediatric Nephrology, Children's Hospital of Hebei Province affiliated to Hebei Medical University, Shijiazhuang, China.
Yanjie HuangDepartment of Pediatrics, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, 450046, China.
Guangmin NongDepartment of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, China.
Xuxu CaiDepartment of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, 110004, Liaoning, PR China.
Huawei MaoDepartment of Immunology, Ministry of Education Key Laboratory of Major Diseases in Children, Beijing Children's Hospital, National Center for Children's Health, Capital Medical University, No. 56 Nanlishi Road, 100045, Beijing, China.
Fei SunDepartment of Immunology, Ministry of Education Key Laboratory of Major Diseases in Children, Beijing Children's Hospital, National Center for Children's Health, Capital Medical University, No. 56 Nanlishi Road, 100045, Beijing, China.
Xiaochuan WuDepartment of Pediatrics, The Second Xiangya Hospital, Central South University, Changsha, China.
Zanhua RongDepartment of paediatrics, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
Jianjiang ZhangDepartment of paediatrics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Zhixiang LiInner Mongolia Autonomous Region People's Hospital, Hohhot, China.
Xinhui JiangGuiyang Maternal and Child Health Care Hospital (Guiyang Children's Hospital), Guiyang, China.
Xiaozhong LiDepartment of Nephrology and Immunology, Children's Hospital of Soochow University, Suzhou, China.
Xuemei LiuQilu Children's Hospital of Shandong University, Jinan, China.
Chongwei LiDepartment of Rheumatology & Immunology, Tianjin Children's Hospital, No. 238 Longyan Road, Beichen District, Tianjin, China.
Lifeng SunDepartment of Pediatrics, Provincial Hospital Affiliated to Shandong University, Jinan, 250021, China.
Sihao GaoDepartment of Pediatrics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
Jun YangRheumatology & Immunology Department of Shenzhen Children's Hospital, Shenzhen, China. rogasansz@163.com.
Hongmei SongDepartment of Pediatrics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China. songhm1021@126.com.
Xuemei TangDepartment of Rheumatology and Immunology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders. Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing, China. tangxuemei2008@163.com.
Chinese Alliance of Pediatric Rheumatic and Immunologic Diseases

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study investigates the clinical characteristics and outcomes of pediatric patients with rheumatic diseases infected with COVID-19 in China.

methodsWe conducted a retrospective analysis of pediatric patients with rheumatic diseases who contracted COVID-19. Data were collected via a comprehensive questionnaire with a 14-day follow-up. Multivariable logistic regression was used to assess severe outcomes, and network analyses evaluated symptom correlations.

resultsA total of 1070 cases were collected. Fever (88.05%) and cough (62.75%) were the most common symptoms. Cough, nasal congestion, and runny nose exhibited a stronger correlation with each other. A higher incidence of fever reduced the incidence of two single symptoms (nasal congestion [r = -0.833], runny nose [r = -0.762]). Vaccinated children showed a shorter time to negative COVID-19 conversion (7.21 days vs. 7.63 days, p < 0.05) and lower hospitalization rates (p = 0.025). Prolonged symptom duration was associated with older age (OR: 1.07 [1.04-1.11]; p < 0.001) and systemic lupus erythematosus (OR: 1.47 [1.01-2.12]; p = 0.046).

conclusionsPediatric patients with rheumatic diseases exhibited a wide range of clinical symptoms after COVID-19 infection. The infection generally did not lead to severe outcomes in this study. COVID-19 vaccination was associated with reduced hospitalization risk and expediting the time to negativity for virus. IMPACTS: This manuscript demonstrates a comprehensive analysis of the clinical characteristics and outcomes of COVID-19 infection in pediatric patients with rheumatic diseases in China. It provides critical insights into the specific challenges faced by this vulnerable population and offers practical recommendations for improving patient management during periods of increased infectious risk.

Indexed as

COVID-19Rheumatic DiseasesSARS-CoV-2AdolescentAge FactorsChildChild, PreschoolChinaCOVID-19 VaccinesFemaleFeverHospitalizationHumansIncidenceInfantInfant, NewbornCOVID-19 Vaccines

Identifiers

PMID39375504
PMCPMC12122361

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