SynthesisScientific reports2024
Comparative study for fatigue prevalence in subjects with diseases: a systematic review and meta-analysis.
Synthesis in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The 2026 British Society for Rheumatology guideline for the management of children, young people and adults with systemic lupus erythematosus.Rheumatology (Oxford, England) · 2026Guideline
- Impact of resistance exercise and diet on physical activity, sleep, and fatigue in obese individuals: a randomized controlled trial.BMC public health · 2025Trial
- Resting state brain connectivity of pain and fatigue is affected by performance of a fatiguing attention task in patients with chronic pain.Neuroimage. Reports · 2026Article
- Sex Differences in the Neuropsychiatric Symptoms of Multiple Sclerosis: Symptômes neuropsychiatriques de la sclérose en plaques: différences selon le sexe.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2026Article
- Article
- Fatigue Trajectory During the First Year of an Inflammatory Bowel Disease Diagnosis, Results from the IBSEN III study.Digestive diseases and sciences · 2026Article
- A mouse model to study persistent fatigue.Research square · 2026Article
- Urinary metabolites and fatigue in a population-based metabolomics study: an exploratory analysis.Metabolomics : Official journal of the Metabolomic Society · 2026Article
- Article
- Targeting dyspnoea through exercise intensity: insights from pulmonary rehabilitation and beyond, a narrative review.Frontiers in rehabilitation sciences · 2026Review
- Fatigue after pulmonary embolism-prevalence and predictors.Frontiers in cardiovascular medicine · 2026Article
- The role of disease history score in the association between depression history and current ME/CFS among US adults.Frontiers in public health · 2026Article
- Protocol for a multicenter observational study on fatigue across physical-mental conditions within the German center for mental health.Frontiers in psychiatry · 2026Article
- Evaluation of occupational fatigue among Chinese nursing managers: a cross-sectional online study.Frontiers in public health · 2026Article
- Health-related quality of life and demographic profiling of patients with selected noncommunicable diseases.Health SA = SA Gesondheid · 2026Article
- Exploring the Interplay Between Fatigue and the Oral Microbiome: A Longitudinal Approach.Microorganisms · 2025Article
- Online survey of fatigue and associated factors among university students in Riyadh Saudi Arabia.Scientific reports · 2025Article
- The association of physical activity with perceived fatigability among community-dwelling older adults aged ≥60 years in regional China.Preventive medicine reports · 2025Article
- Bibliometric and visual analysis of overlooked fatigue in kidney transplantation: a narrative review.Annals of medicine and surgery (2012) · 2025Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Fatigue is one of the common symptoms in individuals with diseases or disorders, significantly affecting quality of life (QoL) and the prognosis of diseases. This study aimed to comprehensively compare the features of fatigue across a wide range of diseases. We systematically searched the PubMed and Cochrane Library databases from inception to March 31st, 2021, and conducted a meta-analysis to generate precise estimates. The analyses were stratified by classification of diseases, gender, and severity of fatigue (moderate and severe), and study quality was assessed using the Newcastle-Ottawa Scale (NOS). In total, 214 articles (233 prevalence data) met our eligibility criteria, covering 102,024 participants (mean 438 ± 1,421) across 88 diseases. Among these, seventy-eight data sets (52,082 participants) and thirty-nine data sets (10,389 participants) reported gender- and severity-related fatigue prevalence. The overall prevalence among subjects with 88 diseases was 49.4% [95% CI 46.9-52.1]. According to the International Classification of Diseases-10 (ICD-10) classification, the highest prevalence of fatigue (65.9% [95% CI 54.9-79.6]) was observed in patients with mental/behavioral diseases, whereas the lowest prevalence (34.7% [95% CI 24.5-49.2]) was found among those with circulatory system diseases. A slight female dominance (43.5% vs. 49.8%) was observed in the total data, with the most notable female predominance (1.8-fold) seen in patients with low back pain. The top disease groups with a moderate to severe level of fatigue included gastroparesis (92.3%), pulmonary hypertension (90.0%), chronic obstructive pulmonary disease (COPD, 83.2%), and multiple sclerosis (80.0%). These results are the first to comprehensively show the comparative features of fatigue prevalence among subjects across 88 diseases. Our findings provide valuable reference data for future research on fatigue and for the management of patients with fatigue.Prospero registration number: CRD42021270494.
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