ArticleNature communications2024
Endothelial Piezo1 channel mediates mechano-feedback control of brain blood flow.
Abstract read
In one paragraph
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed.
- Opposing blood-contacting surfaces of the human cavernous internal carotid artery: a segmental and topographic immunofluorescence study.Surgical and radiologic anatomy : SRA · 2026Article
- Endothelial Piezo1 Hyperactivity Drives Neurovascular Dysfunction in Hypertension.Circulation research · 2026Article
- Epigenetic markers of response to psychotherapy in obsessive-compulsive disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Neurovascular Signaling in the Perivascular Space: Biophysical Principles and Disruption in Hypertension.Hypertension (Dallas, Tex. : 1979) · 2026Review
- Cerebral venous blood flow regulates intracerebral pressure and brain clearance via meningeal lymphatic vessels.Nature neuroscience · 2026Article
- Tau protein differentially affects Piezo1 and Kir2.1 channels in brain capillary endothelial cells.Biophysical journal · 2026Article
- Article
- Knockdown of endothelial Serpine1 improves stroke recovery by attenuating peri-infarct blood flow and blood-brain barrier disruption.Cell death & disease · 2026Article
- Voltage-Dependent Ion Channels in Vascular Endothelial Cells: An Unexpected Signaling Pathway in Non-Excitable Cells.Biomedicines · 2026Review
- Research status and trends of Piezo1 and brain: A bibliometric analysis.Neuroprotection (Chichester, England) · 2026Article
- The Piezo1-Ca2+-PI3k/Akt signaling axis as a context-dependent mechanotransduction node during skin wound healing.iScience · 2026Review
- Piezo1 in the central nervous system: decoding the mechanical signature of neuroinflammation.Journal of neuroinflammation · 2026Review
- Cerebral capillary computation.American journal of physiology. Cell physiology · 2026Review
- Mechanochemical regulation of organoid morphogenesis: Integrated signaling circuits in engineered microenvironments.Materials today. Bio · 2026Review
- Antioxidation is a Common Defense Strategy for Different Species Under Mechanical Stress.Advanced genetics (Hoboken, N.J.) · 2026Article
- Capillary-Associated Microglia in Neurovascular Coupling: Localization, Mechanisms, and Disease Implications.Journal of neuroinflammation · 2026Review
- The Emerging Role of Endothelial Ion Channels in the Control of Human Microcirculation.International journal of molecular sciences · 2026Review
- Exploring the Therapeutic Potential of Piezo1 in Ageing-Related Neurodegenerative Diseases.Journal of molecular neuroscience : MN · 2026Review
- Pericytes as key mediators of microenvironmental signaling crosstalk: implications in vascular diseases and cancer.Frontiers in cell and developmental biology · 2026Review
- Brain Capillary Ion Channels: Physiology and Channelopathies.Physiology (Bethesda, Md.) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Xin Rui Lim *Department of Pharmacology, Larner College of Medicine, University of Vermont, Burlington, VT, USA.ORCID 0000-0002-4166-0377
Mohammad M Abd-Alhaseeb *Department of Pharmacology, Larner College of Medicine, University of Vermont, Burlington, VT, USA.ORCID 0000-0001-5388-5250
Michael IppolitoDepartment of Pharmacology, Larner College of Medicine, University of Vermont, Burlington, VT, USA.ORCID 0009-0007-0135-0415
Masayo KoideDepartment of Pharmacology, Larner College of Medicine, University of Vermont, Burlington, VT, USA.
Amanda J SenatoreDepartment of Pharmacology, Larner College of Medicine, University of Vermont, Burlington, VT, USA.
Curtis PlanteDepartment of Pharmacology, Larner College of Medicine, University of Vermont, Burlington, VT, USA.
Ashwini HariharanDepartment of Physiology, School of Medicine, University of Maryland, Baltimore, MD, USA.
Nick WeirDepartment of Physiology, School of Medicine, University of Maryland, Baltimore, MD, USA.
Thomas A LongdenDepartment of Physiology, School of Medicine, University of Maryland, Baltimore, MD, USA.ORCID 0000-0002-7950-7677
Kathryn A LapradeDepartment of Neurological Sciences, Larner College of Medicine, University of Vermont, Burlington, VT, USA.
James M StaffordDepartment of Neurological Sciences, Larner College of Medicine, University of Vermont, Burlington, VT, USA.
Dorothea ZiemensInstitute of Experimental and Clinical Pharmacology and Toxicology, Center of Brain, Behavior and Metabolism (CBBM), University of Lübeck, Lübeck, Germany.
Markus SchwaningerInstitute of Experimental and Clinical Pharmacology and Toxicology, Center of Brain, Behavior and Metabolism (CBBM), University of Lübeck, Lübeck, Germany.ORCID 0000-0002-4510-9718
Jan WenzelInstitute of Experimental and Clinical Pharmacology and Toxicology, Center of Brain, Behavior and Metabolism (CBBM), University of Lübeck, Lübeck, Germany.ORCID 0000-0001-6313-2439
Dmitry D PostnovCenter of Functionally Integrative Neuroscience, Department of Clinical Medicine, Aarhus University, Aarhus, 8200, Denmark.
Osama F HarrazDepartment of Pharmacology, Larner College of Medicine, University of Vermont, Burlington, VT, USA. Osama.Harraz@uvm.edu.ORCID 0000-0003-2061-1100
Funding
Understanding Factors Influencing COVID-19 Testing and Vaccination in Immigrant Low-income and Homeless Populations and Testing Targeted InterventionsU54GM115516 · NIGMS · MAINEHEALTH · PI Kimberly Luebbers · 2017 to 2026
$51.6MVermont Center for Cardiovascular and Brain HealthP20GM135007 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI Kathryn H Morelli · 2020 to 2026
$17.4MCapillaries as a Sensory Web that Controls Cerebral Blood Flow in Health and DiseaseR35HL140027 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI NELSON, MARK T · 2019 to 2025
$6.3MInvestigating the Microvascular Mechanisms of O2 Supply-Demand Mismatch in Small Vessel Disease using Novel High-Resolution Optical ImagingR01NS115401 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI AYATA, CENK, SAKADZIC, SAVA · 2020 to 2024
$3.5MPericytes as metabolic sentinels in the control of brain blood flow in health and Alzheimer's diseaseR01AG066645 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI Thomas A Longden · 2020 to 2026
$2.5MVascular Signaling Plasticity - Novel Concepts and Tools for Studying Neurovascular Interactions in Health and DiseaseDP2NS121347 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI LONGDEN, THOMAS A · 2020 to 2020
$2.3MEndothelial Piezo1 channel and cerebral blood flow controlR01HL169681 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI Osama F Harraz · 2023 to 2026
$2.3MAUTS2 and the chromatin dynamics of alcohol use disordersR00AA024837 · NIAAA · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI STAFFORD, JAMES M · 2019 to 2021
$747kBrain capillary Piezo1 ion channels and blood flow regulation in Alzheimer’s DiseaseR21AG082193 · NIA · UNIVERSITY OF MIAMI CORAL GABLES · PI BRACKO, OLIVER, HARRAZ, OSAMA F · 2023 to 2024
$434kAmerican Heart Association (American Heart Association, Inc.) 20CDA35310097American Heart Association-American Stroke Association 20CDA35310097 - OSAMA HARRAZNHLBI NIH HHS R01 HL169681NHLBI NIH HHS R35 HL140027NIAAA NIH HHS R00 AA024837NIA NIH HHS R01 AG066645NIA NIH HHS R21 AG082193NIGMS NIH HHS P20 GM135007NIGMS NIH HHS U54 GM115516NINDS NIH HHS DP2 NS121347NINDS NIH HHS R01 NS115401Silicon Valley Community Foundation (SVCF) 2024-338506U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL169681U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) P20GM135007U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) R21AG082193
Abstract
Hyperemia in response to neural activity is essential for brain health. A hyperemic response delivers O
Indexed as
BrainCerebrovascular CirculationIon ChannelsAnimalsEndothelial CellsFeedback, PhysiologicalFemaleHyperemiaMaleMechanotransduction, CellularMiceMice, Inbred C57BLMice, KnockoutIon ChannelsPiezo1 protein, mouse
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.