Evidence map›Paper›PMID 39375308›Full record

ArticleHistopathology2025

A new algorithm for coeliac disease based on the 'long forgotten' TCRγδ

Eda N Kozan, Bilge A Kırmızı, Ceyda T Kirsaclioglu, Derya Gokmen, Berna Savas, Aydan Kansu, Arif I Soykan, Arzu Ensari

Abstract read
In one paragraph

Article in Histopathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Eda N KozanDepartment of Pathology, Ankara University Medical School, Ankara, Turkey.ORCID https://orcid.org/0000-0001-8363-5068
Bilge A KırmızıDepartment of Pathology, Ankara University Medical School, Ankara, Turkey.ORCID https://orcid.org/0000-0003-3192-1921
Ceyda T KirsacliogluDepartment of Pediatric Gastroenterology, Ankara University Medical School, Ankara, Turkey.ORCID https://orcid.org/0000-0002-3551-7267
Derya GokmenDepartment of Biostatistics, Ankara University Medical School, Ankara, Turkey.ORCID https://orcid.org/0000-0001-6266-3035
Berna SavasDepartment of Pathology, Ankara University Medical School, Ankara, Turkey.ORCID https://orcid.org/0000-0003-3971-1419
Aydan KansuDepartment of Pediatric Gastroenterology, Ankara University Medical School, Ankara, Turkey.ORCID https://orcid.org/0000-0002-3133-9846
Arif I SoykanDepartment of Gastroenterology, Ankara University Medical School, Ankara, Turkey.ORCID https://orcid.org/0000-0002-5971-4361
Arzu EnsariDepartment of Pathology, Ankara University Medical School, Ankara, Turkey.ORCID https://orcid.org/0000-0001-7036-4457

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsDiagnosis of coeliac disease (CD) with mild mucosal changes is difficult for all parties involved. We aimed to determine the power of T cell receptor (TCR)γδ

methodsA total of 167 cases categorised as coeliac (117 untreated CD, classified according to Marsh, updated by Ensari, including 29 type 1, 29 type 2, 39 type 3 and 20 treated CD), and non-coeliac groups (24 controls and 26 non-coeliac IELosis) based on clinical, serological and histological data were studied for IEL counts enumerated per 100 enterocytes using haematoxylin and eosin, CD3, TCR δ-stains.

resultsTCRγδ

conclusionsThe new antibody detecting γδ

Indexed as

AlgorithmsCeliac DiseaseIntraepithelial LymphocytesReceptors, Antigen, T-Cell, gamma-deltaAdolescentAdultAgedAntibodies, MonoclonalFemaleHumansIntestinal MucosaMaleMiddle AgedSensitivity and SpecificityYoung AdultAntibodies, MonoclonalReceptors, Antigen, T-Cell, gamma-deltacoeliac diseaseintra‐epithelial lymphocytesT cell receptor gamma delta

Identifiers

PMID39375308
PMCPMC11707493

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.