Evidence map›Paper›PMID 39375286›Full record

ArticleMolecular neurobiology2025

Brain Abnormalities in Young Single- and Double-Heterozygote Mice for Both Nkx2-1- and Pax8-Null Mutations.

Antonia Giacco, Stefania Iervolino, Federica Cioffi, Teresa Peluso, Giovanna Mercurio, Luca Roberto, Valeria de Rosa, Mariarosaria Cammarota, Silvia Varricchio, Stefania Staibano and 6 more

Abstract read
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In one paragraph

Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Antonia GiaccoDepartment of Science and Technology, University of Sannio, Via De Sanctis, 82100, Benevento, Italy.
Stefania IervolinoDepartment of Science and Technology, University of Sannio, Via De Sanctis, 82100, Benevento, Italy.
Federica CioffiDepartment of Science and Technology, University of Sannio, Via De Sanctis, 82100, Benevento, Italy.
Teresa PelusoDepartment of Science and Technology, University of Sannio, Via De Sanctis, 82100, Benevento, Italy.
Giovanna MercurioDepartment of Science and Technology, University of Sannio, Via De Sanctis, 82100, Benevento, Italy.
Luca RobertoBiogem, Biology and Molecular Genetics Institute, Via Camporeale, 83031, Ariano Irpino, Av, Italy.
Valeria de RosaDivision of Pharmacology, Department of Neuroscience, Reproductive and Dentistry Sciences, School of Medicine, Federico II University of Naples, Via Pansini, 5, 80131, Naples, Italy.
Mariarosaria CammarotaDivision of Pharmacology, Department of Neuroscience, Reproductive and Dentistry Sciences, School of Medicine, Federico II University of Naples, Via Pansini, 5, 80131, Naples, Italy.
Silvia VarricchioDepartment of Advanced Biomedical Sciences, Pathology Section, University of Naples Federico II, 80131, Naples, Italy.
Stefania StaibanoDepartment of Advanced Biomedical Sciences, Pathology Section, University of Naples Federico II, 80131, Naples, Italy.
Francesca BosciaDivision of Pharmacology, Department of Neuroscience, Reproductive and Dentistry Sciences, School of Medicine, Federico II University of Naples, Via Pansini, 5, 80131, Naples, Italy.
Lorella Maria Teresa CanzonieroDepartment of Science and Technology, University of Sannio, Via De Sanctis, 82100, Benevento, Italy.
Mario De FeliceInstitute of Experimental Endocrinology and Oncology (IEOS), CNR, Via Pansini 6, 80131, Naples, Italy.
Concetta AmbrosinoDepartment of Science and Technology, University of Sannio, Via De Sanctis, 82100, Benevento, Italy.
Maria MorenoDepartment of Science and Technology, University of Sannio, Via De Sanctis, 82100, Benevento, Italy.
Elena SilvestriDepartment of Science and Technology, University of Sannio, Via De Sanctis, 82100, Benevento, Italy. silvestri@unisannio.it.ORCID http://orcid.org/0000-0002-0592-9033

Funding

Industrial PhD project, Unisannio F85B18006450006Industrial PhD project, Unisannio Italian Ministry of HealthLegge Regionale 5/02 F82I14001270002
6 · The paper itself

Abstract

In humans and mice, Nkx2-1 and Pax8 are crucial morphogenic transcription factors defining the early development of the thyroid and specific extrathyroidal tissues. By using 3-month-old single or double heterozygotes for Nkx2-1- and Pax8-null mutations (DHTP) mice, we studied brain abnormalities under different human-like dysthyroidisms, focusing on putative alterations of specific neurotransmitter systems, expression of markers of pre- and post-synaptic function and, given the physio-pathological role mitochondria have in controlling the bioenergetic status of neurons, of mitochondrial dynamics and oxidative balance. Compared to Wt controls, DHTP mice, bearing both systemic and brain hypothyroidism, showed altered expression of synaptic markers, generic and cholinergic (corroborated by immunohistochemistry in caudate, putamen, hippocampus, and basal forebrain) and glutamatergic ones, and reduced expression of key proteins of synaptic plasticity potency and several isoforms of glutamate receptors. The brain of DHTP mice was characterized by lower levels of H

Indexed as

BrainHeterozygoteMutationPAX8 Transcription FactorThyroid Nuclear Factor 1AnimalsMaleMiceMitochondriaNkx2-1 protein, mousePax8 protein, mousePAX8 Transcription FactorThyroid Nuclear Factor 1Congenital hypothyroidismMitochondriaOxidative stressSynapses

Identifiers

PMID39375286
PMCPMC11880048

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.