ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2024
The Relationship between White Matter Architecture and Language Lateralization in the Healthy Brain.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Language network functional connectivity in infancy predicts developmental language trajectories.Developmental cognitive neuroscience · 2026Article
- Language laterality and cognitive skills: does anatomy matter?Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Lifespan Trajectories of Asymmetry in White Matter Tracts.Human brain mapping · 2026Article
- Protracted Functional and Structural Reorganization of Human Prefrontal Cortex Supports Lateralized Category Geometries.bioRxiv : the preprint server for biology · 2026Article
- Manifold lateralisation and variability in the language connectome at 7T.Research square · 2026Article
- Does bilingualism buffer genetic predispositions to reading difficulties through alterations of structural interhemispheric connectivity? An ABCDbioRxiv : the preprint server for biology · 2026Article
- The 'hand-brain-emotion' axis: a theoretical model for handicraft art-based intervention in anxiety disorders through neuroplasticity and autonomic regulation.Frontiers in psychology · 2026Review
- Hemispheric asymmetries in resting-state connectivity: insights from healthy controls and implications for neurological disorders.Brain structure & function · 2025Article
- The Shape of the Brain's Connections Is Predictive of Cognitive Performance: An Explainable Machine Learning Study.Human brain mapping · 2025Review
- The Balance in the Head: How Developmental Factors Explain Relationships Between Brain Asymmetries and Mental Diseases.Brain sciences · 2025Review
- Exploring the Relationship Between White Matter Tracts and Resting-State Functional Language Lateralization Index.Neurobiology of language (Cambridge, Mass.) · 2025Article
- Hemispheric consistency in language production, comprehension, and reading in typically and atypically lateralized left-handers: Implications for reading performance.Imaging neuroscience (Cambridge, Mass.)Article
- TheBrain and neuroscience advancesArticle
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interhemispheric anatomical differences have long been thought to be related to language lateralization. Previous studies have explored whether asymmetries in the diffusion characteristics of white matter language tracts are consistent with language lateralization. These studies, typically with smaller cohorts, yielded mixed results. This study investigated whether connectomic analysis of quantitative anisotropy (QA) and shape features of white matter tracts across the whole brain are associated with language lateralization. We analyzed 1,040 healthy individuals (562 females) from the Human Connectome Project database. Hemispheric language dominance for each participant was quantified using a laterality quotient (LQ) derived from fMRI activation in regions of interest (ROIs) associated with a language comprehension task compared against a math task. A linear regression model was used to examine the relationship between structural asymmetry and functional lateralization. Connectometry revealed a significant negative correlation between LQs and QA of corpus callosum tracts, indicating that higher QA in these regions is associated with bilateral and right hemisphere language representation in frontal and temporal regions. Left language laterality in the temporal lobe was significantly associated with longer right inferior fronto-occipital fasciculus (IFOF) and forceps minor tracts. These results suggest that diffusion measures of microstructural architecture as well as geometrical features of reconstructed white matter tracts play a role in language lateralization. People with increased dependence on the right or both frontal hemispheres for language processing may have more developed commissural fibers, which may support more efficient interhemispheric communication.
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