Evidence map›Paper›PMID 39375030›Full record

ArticleeNeuro2024

Sex-Dependent Changes in Gonadotropin-Releasing Hormone Neuron Voltage-Gated Potassium Currents in a Mouse Model of Temporal Lobe Epilepsy.

Remya Rajan, Catherine A Christian-Hinman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eNeuro, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Remya RajanDepartment of Molecular and Integrative Physiology, University of Illinois Urbana-Champaign, Urbana, Illinois 61801.
Catherine A Christian-HinmanDepartment of Molecular and Integrative Physiology, University of Illinois Urbana-Champaign, Urbana, Illinois 61801 cathchri@illinois.edu.ORCID https://orcid.org/0000-0003-3475-2166

Funding

Neural and pituitary mechanisms linking epilepsy to co-morbid reproductive endocrine dysfunctionR01NS105825 · NINDS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI CHRISTIAN-HINMAN, CATHERINE A · 2018 to 2022
$1.8M
NINDS NIH HHS R01 NS105825
6 · The paper itself

Abstract

Temporal lobe epilepsy (TLE) is the most common focal epilepsy in adults, and people with TLE exhibit higher rates of reproductive endocrine dysfunction. Hypothalamic gonadotropin-releasing hormone (GnRH) neurons regulate reproductive function in mammals by regulating gonadotropin secretion from the anterior pituitary. Previous research demonstrated GnRH neuron hyperexcitability in both sexes in the intrahippocampal kainic acid (IHKA) mouse model of TLE. Fast-inactivating A-type (

Indexed as

Disease Models, AnimalEpilepsy, Temporal LobeGonadotropin-Releasing HormoneMice, TransgenicNeuronsSex CharacteristicsAnimalsExcitatory Amino Acid AgonistsFemaleHippocampusKainic AcidMaleMiceMice, Inbred C57BLPatch-Clamp TechniquesPotassium Channels, Voltage-GatedExcitatory Amino Acid AgonistsGonadotropin-Releasing HormoneKainic AcidPotassium Channels, Voltage-GatedGnRHhypothalamuskainic acidseizuresex differences

Identifiers

PMID39375030
PMCPMC11493494

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.