Evidence map›Paper›PMID 39374843›Full record

ArticleVirus research2024

Human pegivirus -1 (HPgV-1) RNA frequency and genotype distribution in pediatric oncology patients with febrile neutropenia.

Anielly Sarana da Silva, Gabriel Montenegro de Campos, Gabriela Marengone Altizani, Alice Chagas Barros, Dennis Maletich Junqueira, Simone Kashima, Sandra Coccuzzo Sampaio, Maria Carolina Elias, Marta Giovanetti, Carlos Alberto Scrideli and 1 more

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In one paragraph

Article in Virus research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Anielly Sarana da SilvaBlood Center of Ribeirão Preto, Faculty of Medicine of Ribeirão Preto, University of São Paulo, 14051-140, Ribeirão Preto, SP, Brazil.
Gabriel Montenegro de CamposBlood Center of Ribeirão Preto, Faculty of Medicine of Ribeirão Preto, University of São Paulo, 14051-140, Ribeirão Preto, SP, Brazil.
Gabriela Marengone AltizaniDepartment of Childcare and Pediatrics, Faculty of Medicine of Ribeirão Preto, University of São Paulo, 14049-900, Ribeirão Preto, SP, Brazil.
Alice Chagas BarrosCentral Laboratory of the General Hospital of Ribeirão Preto, Faculty of Medicine of Ribeirão Preto, University of São Paulo, 14040-030, Ribeirão Preto, SP, Brazil.
Dennis Maletich JunqueiraLaboratory of Bioinformatics and Virus Evolution, Department of Biochemistry and Molecular Biology, Center for Natural and Exact Sciences (CCNE), Federal University of Santa Maria, 97105-900, Santa Maria, RS, Brazil.
Simone KashimaBlood Center of Ribeirão Preto, Faculty of Medicine of Ribeirão Preto, University of São Paulo, 14051-140, Ribeirão Preto, SP, Brazil.
Sandra Coccuzzo SampaioCenter for Viral Surveillance and Serologic Evaluation (CeVIVAs), Butantan Institute, 05503-001, São Paulo, SP, Brazil.
Maria Carolina EliasCenter for Viral Surveillance and Serologic Evaluation (CeVIVAs), Butantan Institute, 05503-001, São Paulo, SP, Brazil.
Marta GiovanettiDepartment of Science and Technology for Humans and the Environment, University of Campus Bio-Medico di Roma, 00128 Rome, Italy; Instituto Rene Rachou, Fundação Oswaldo Cruz, Belo Horizonte 30190-002, MG, Brazil; Climate Amplified Diseases and Epidemic (CLIMADE), Brasília 30190-002, DF, Brazil.
Carlos Alberto ScrideliDepartment of Childcare and Pediatrics, Faculty of Medicine of Ribeirão Preto, University of São Paulo, 14049-900, Ribeirão Preto, SP, Brazil.
Svetoslav Nanev SlavovCenter for Viral Surveillance and Serologic Evaluation (CeVIVAs), Butantan Institute, 05503-001, São Paulo, SP, Brazil. Electronic address: svetoslav.slavov@fundacaobutantan.org.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human Pegivirus-1, typically regarded as a commensal virus, exhibits high prevalence in humans. Its frequency and impact on oncologic pediatric patients with febrile neutropenia (FN), a frequent chemotherapy complication, remains unexplored. In this study, we assessed HPgV-1 RNA prevalence in pediatric patients experiencing FN. Blood samples were collected from 30 children, 15 presenting FN and 15 comprising a control group of either undergoing treatment or in remission. Overall, HPgV-1 RNA was detected in 23.3 % of samples (26.7 % among FN patients and 20.0 % among those under treatment or in remission). Phylogenetic analysis unveiled HPgV-1 genotype 2 predominance among these samples, the most prevalent strain circulating in Brazil. Our findings prompt crucial inquiries into the role of HPgV-1 RNA in FN: is it an incidental finding and if it can influences this clinical entity? Further investigation is imperative to elucidate HPgV-1 implications in vulnerable patients cohorts, potentially informing new approaches and understanding viral dynamics in immunocompromised populations.

Indexed as

Febrile NeutropeniaFlaviviridae InfectionsGenotypeNeoplasmsPegivirusPhylogenyRNA, ViralAdolescentBrazilChildChild, PreschoolFemaleHumansInfantMalePrevalenceRNA, ViralFebrile neutropeniaHuman pegivirus-1OncologyPediatric patients

Identifiers

PMID39374843
PMCPMC11736395

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.