Evidence map›Paper›PMID 39374783›Full record

ArticleThe Journal of biological chemistry2024

The unique Pt(II)-induced nucleolar stress response and its deviation from DNA damage response pathways.

Hannah C Pigg, Katelyn R Alley, Christopher R Griffin, Caleb H Moon, Sarah J Kraske, Victoria J DeRose

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. bioRxiv : the preprint server for biology · 2026
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hannah C PiggDepartment of Chemistry and Biochemistry, University of Oregon, Eugene, Oregon, USA.
Katelyn R AlleyDepartment of Chemistry and Biochemistry, University of Oregon, Eugene, Oregon, USA.
Christopher R GriffinDepartment of Chemistry and Biochemistry, University of Oregon, Eugene, Oregon, USA.
Caleb H MoonDepartment of Chemistry and Biochemistry, University of Oregon, Eugene, Oregon, USA.
Sarah J KraskeDepartment of Chemistry and Biochemistry, University of Oregon, Eugene, Oregon, USA.
Victoria J DeRoseDepartment of Chemistry and Biochemistry, University of Oregon, Eugene, Oregon, USA. Electronic address: derose@uoregon.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The mechanisms of action for the platinum compounds cisplatin and oxaliplatin have yet to be fully elucidated, despite the worldwide use of these drugs. Recent studies suggest that the two compounds may be working through different mechanisms, with cisplatin inducing cell death via the DNA damage response (DDR) and oxaliplatin utilizing a nucleolar stress-based cell death pathway. While cisplatin-induced DDR has been subject to much research, the mechanisms for oxaliplatin's influence on the nucleolus are not well understood. Prior work has outlined structural parameters for Pt(II) derivatives capable of nucleolar stress induction. In this work, we gain insight into the nucleolar stress response induced by these Pt(II) derivatives by investigating potential correlations between this unique pathway and DDR. Key findings from this study indicate that Pt(II)-induced nucleolar stress occurs when DDR is inhibited and works independently of the ATM/ATR-dependent DDR pathway. We also determine that Pt(II)-induced stress may be linked to the G

Indexed as

Cell NucleolusCisplatinDNA DamageAntineoplastic AgentsAtaxia Telangiectasia Mutated ProteinsCell Cycle ProteinsCell Line, TumorHumansOrganoplatinum CompoundsOxaliplatinStress, PhysiologicalAntineoplastic AgentsAtaxia Telangiectasia Mutated ProteinsATM protein, humanATR protein, humanCell Cycle ProteinsCisplatinOrganoplatinum CompoundsOxaliplatinDDRnucleolar stressnucleolusoxaliplatinplatinumPt(II)

Identifiers

PMID39374783
PMCPMC11612370

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.