Evidence map›Paper›PMID 39374741›Full record

ArticleRespiratory medicine

Hyperpolarized

Madison Kocher Wulfeck, David G Mummy, Shuo Zhang, Diana Kadi, Stacy Goins, Aparna Swaminathan, Robert M Tighe, Bastiaan Driehuys, Joseph G Mammarappallil

Abstract read
In one paragraph

Article in Respiratory medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. The emerging role of hyperpolarizedExpert review of respiratory medicine · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Madison Kocher WulfeckDepartment of Radiology, Duke University Medical Center, 2301 Erwin Road Box 3808, Durham, NC, 27710, USA. Electronic address: madison.wulfeck@radpartners.com.
David G MummyDepartment of Radiology, Duke University Medical Center, 2301 Erwin Road Box 3808, Durham, NC, 27710, USA. Electronic address: David.mummy@duke.edu.
Shuo ZhangDepartment of Radiology, Duke University Medical Center, 2301 Erwin Road Box 3808, Durham, NC, 27710, USA. Electronic address: Shuo.zhang@duke.edu.
Diana KadiDepartment of Radiology, Duke University Medical Center, 2301 Erwin Road Box 3808, Durham, NC, 27710, USA. Electronic address: Diana.kadi@duke.edu.
Stacy GoinsDepartment of Radiology, Duke University Medical Center, 2301 Erwin Road Box 3808, Durham, NC, 27710, USA. Electronic address: Stacy.goins@duke.edu.
Aparna SwaminathanDepartment of Medicine, Duke University Medical Center, USA. Electronic address: Aparna.swaminathan@duke.edu.
Robert M TigheDepartment of Medicine, Duke University Medical Center, USA. Electronic address: Robert.tighe@duke.edu.
Bastiaan DriehuysDepartment of Radiology, Duke University Medical Center, 2301 Erwin Road Box 3808, Durham, NC, 27710, USA. Electronic address: Bastiaan.driehuys@duke.edu.
Joseph G MammarappallilDepartment of Radiology, Duke University Medical Center, 2301 Erwin Road Box 3808, Durham, NC, 27710, USA. Electronic address: Joseph.mammarappallil@duke.edu.

Funding

Early Detection of Changes in Pulmonary Gas Exchange by Hyperpolarized Xe MRIR01HL105643 · NHLBI · DUKE UNIVERSITY · PI Bastiaan Driehuys · 2011 to 2026
$6.7M
Using MRI To Visualize Regional Therapy Response In Idiopathic Pulmonary FibrosisR01HL126771 · NHLBI · DUKE UNIVERSITY · PI Bastiaan Driehuys · 2015 to 2026
$6.6M
NHLBI NIH HHS R01 HL105643NHLBI NIH HHS R01 HL126771
6 · The paper itself

Abstract

purposeTo evaluate 3D gas-exchange functional imaging characteristics using

methodsIn this prospective study, 11 participants with clinical and CT findings of CHP (4M 7F, mean age 67 ± 6.1 years) as well as 41 healthy subjects (25M 16F, mean age 44 ± 18 years) were enrolled between 2017 and 2022 and underwent

resultsCHP participants demonstrated significant differences in 6 parameters (p < 0.001) including regions of reduced ventilation, increased membrane uptake, and reduced RBC transfer as compared to healthy subjects. Gas exchange abnormalities measured on spectroscopy included a reduced RBC:M, reduced RBC chemical shift, and increased RBC oscillation amplitude.

conclusionIn participants with CHP,

Indexed as

Alveolitis, Extrinsic AllergicMagnetic Resonance ImagingPulmonary Gas ExchangeXenon IsotopesAdultAgedChronic DiseaseFemaleHumansImaging, Three-DimensionalMaleMiddle AgedProspective StudiesXenon-129Xenon Isotopes(129)Xe MRIChronic hypersensitivity pneumonitisHigh-resolution computed tomographyInterstitial lung disease

Identifiers

PMID39374741
PMCPMC11588504

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.