Trial reportBlood advances2024
Digital cognitive behavioral therapy vs education for pain in adults with sickle cell disease.
Trial report in Blood advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Emerging trends and hotspots in cognitive behavioral therapy for chronic pain: a bibliometric analysis.Frontiers in medicine · 2026Pooled it
- Experiences With a Multicomponent Digital Behavioral Pain Management Intervention for Adults With Sickle Cell Disease: Qualitative Analysis of the CaRISMA Trial.JMIR human factors · 2025Trial
- Article
- Patient Experiences of Acute Pain Communication in Sickle Cell Disease and Perspectives on Improving Clinician Communication.Journal of clinical psychology in medical settings · 2026Article
- Efficacy of AI-delivered cognitive behavioral therapy interventions for anxiety and depressive symptoms: a systematic review.NPJ digital medicine · 2026Article
- Article
- Sickle cell pain: call for whole person health approaches to mechanisms-informed integrative management.Blood advances · 2026Article
- Increasing engagement with cognitive-behavioral therapy (CBT) using generative AI: a randomized controlled trial (RCT).Communications medicine · 2026Article
- Adapting a school readiness intervention for children with sickle cell disease: an intervention mapping for adaptation approach.Frontiers in public health · 2026Article
- The right patient, the right treatment: tailoring sickle cell disease care.Hematology. American Society of Hematology. Education Program · 2025Review
- Health equity in sickle cell disease: overcoming barriers to care in marginalized communities.Annals of medicine and surgery (2012) · 2025Review
- Prospective cohort study of eDiary acute pain assessments in sickle cell disease during third trimester and postpartum.Blood advances · 2025Article
- Patient Perspectives on Enhancing Clinician Communication About Pain in Sickle Cell Disease.Research square · 2025Article
- Deciphering Pain Experience in Adult Patients With Sickle Cell Disease: A Network Analysis of Pain-Related Factors in a Single French Sickle Cell Centre.European journal of pain (London, England) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors.
Funding
Abstract
abstractDespite the burden of chronic pain in sickle cell disease (SCD), nonpharmacological approaches remain limited. This multisite, randomized trial compared digital cognitive behavioral therapy (CBT) with a digital pain/SCD education program ("Education") for managing pain and related symptoms. Participants were recruited virtually from seven SCD centers and community organizations in the United States. Adults (aged ≥18 years) with SCD-related chronic pain and/or daily opioid use were assigned to receive either CBT or Education for 12 weeks. Both groups used an app with interactive chatbot lessons and received personalized health coach support. The primary outcome was the change in pain interference at six months, with secondary outcomes including pain intensity, depression, anxiety, quality of life, and self-efficacy. Of 453 screened participants, 359 (79%) were randomized to CBT (n = 181) or Education (n = 178); 92% were Black African American, and 66.3% were female. At six months, 250 participants (70%) completed follow-up assessments, with 16 (4%) withdrawals. Engagement with the chatbot varied, with 76% connecting and 48% completing at least one lesson, but 80% of participants completed at least one health coach session. Both groups showed significant within-group improvements in pain interference (CBT: -2.13; Education: -2.66), but no significant difference was observed between them (mean difference, 0.54; P = .57). There were no between-group differences in pain intensity, depression, anxiety, or quality of life. High engagement with health coaching and variable engagement with digital components may explain the similar outcomes between interventions in this diverse, hard-to-reach population.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.