Evidence map›Paper›PMID 39374542›Full record

ArticleEuropean journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery2024

Risk factors and early outcomes associated with prolonged pleural effusion/chylothorax after paediatric cardiac surgery.

Dan M Dorobantu, Peter Davis, Katherine Brown, Deborah Ridout, Paul Wellman, Jane Cassidy, Christina Pagel, Warren Rodrigues, Serban C Stoica

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dan M DorobantuChildren's Health and Exercise Research Center, University of Exeter, Exeter, UK.ORCID 0000-0003-2443-1019
Peter DavisCardiology and Intensive Care Departments, Bristol Royal Hospital for Children and the Heart Institute, Bristol, UK.
Katherine BrownIntensive Care Unit Department, Great Ormond Street Hospital for Children, London, UK.ORCID 0000-0002-0729-4959
Deborah RidoutPopulation, Policy and Practice Programme, University College London, London, UK.
Paul WellmanIntensive Care Unit Department, Evelina London Children's Hospital, London, UK.
Jane CassidyIntensive Care Unit Department, Birmingham Children's Hospital, Birmingham, UK.
Christina PagelPopulation, Policy and Practice Programme, University College London, London, UK.ORCID 0000-0002-2857-1628
Warren RodriguesIntensive Care Unit Department, Great Ormond Street Hospital for Children, London, UK.
Serban C StoicaCardiology and Intensive Care Departments, Bristol Royal Hospital for Children and the Heart Institute, Bristol, UK.

Funding

National Institute for Health Research, Health Services and Delivery Research Program 12/5005/06
6 · The paper itself

Abstract

objectivesProlonged pleural effusion/chylothorax (PPE/C) is a less investigated complication following paediatric cardiac surgery, and its true incidence, risk factors and impact on postoperative outcomes are not well described. We aim to address these gaps in knowledge using data from a prospective, multicentre study.

methodsData on 9 post-operative morbidities (unplanned reinterventions, extracorporeal life support, necrotising enterocolitis, PPE/C, renal replacement therapy, major adverse events, acute neurological events, feeding issues and postsurgical infection) were prospectively collected at 5 UK centres between 2015 and 2017, following paediatric cardiac surgery. Incidence of PPE/C, associations with procedure types, and risk factors were described. Mortality (30-day and 6-month) and hospital length of stay (HLoS) were compared between those with isolated PPE/C, single non-PPE/C morbidity, no morbidity, multimorbidity PPE/C and non-PPE/C multimorbidity.

resultsA total of 3090 procedures (2861 patients) were included (median age, 228 days). There were 202 PPE/C (incidence of 6.5%), occurring at a median of 6 days postoperatively (interquartile range: 3-10). PPE/C was associated with excess early mortality only when complicating scenarios where at least 2 other post-operative morbidities occurred. On average PPE/C is associated with 8 more HLoS days, but the relative impact is greatest when comparing isolated PPE/C with no morbidity (P < 0.001), whereas in multimorbidity scenarios, PPE/C does not significantly contribute to an increase of HLoS.

conclusionsAddition of PPE/C increases mortality but not HLoS in multimorbidity and HLoS only in single morbidity scenarios. This reinforces the important role of prevention, early detection and management of PPE/C in complex situations.

Indexed as

Cardiac Surgical ProceduresChylothoraxPleural EffusionPostoperative ComplicationsChildChild, PreschoolFemaleHumansIncidenceInfantInfant, NewbornLength of StayMaleProspective StudiesRisk FactorsUnited KingdomChylothoraxCongenital heart diseaseMorbidityPaediatric cardiac surgeryPleural effusionProspective study

Identifiers

PMID39374542
PMCPMC11522863

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.