Evidence map›Paper›PMID 39374416›Full record

ArticleOrganic letters2024

Organophotocatalytic Selective Deuteration of Metabolically Labile Heteroatom Adjacent C-H Bonds via H/D Exchange with D

Xiang Meng, Chao Che, Yue Dong, Qiangqiang Liu, Wei Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Organic letters, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xiang MengDepartment of Pharmacology & Toxicology, University of Arizona, Tucson, Arizona 85721, United States.
Chao CheDepartment of Pharmacology & Toxicology, University of Arizona, Tucson, Arizona 85721, United States.
Yue DongDepartment of Pharmacology & Toxicology, University of Arizona, Tucson, Arizona 85721, United States.
Qiangqiang LiuDepartment of Pharmacology & Toxicology, University of Arizona, Tucson, Arizona 85721, United States.
Wei WangDepartment of Pharmacology & Toxicology, University of Arizona, Tucson, Arizona 85721, United States.ORCID 0000-0001-6043-0860

Funding

Organocatalytic Practical Synthesis of Deuterated Building Blocks and Biologically Important StructuresR01GM125920 · NIGMS · UNIVERSITY OF NEW MEXICO · PI WANG, WEI · 2018 to 2021
$1.2M
NIGMS NIH HHS R01 GM125920
6 · The paper itself

Abstract

We report a general approach for efficient deuteration of the metabolically labile α-C-H bonds of widespread amides and amines. Temporarily masking the secondary amine group as a carbamate allows an unprecedented photoredox hydrogen atom transfer-promoted α-carbamyl radical formation for efficient H/D exchange with D

Indexed as

AmidesAminesCatalysisDeuteriumDeuterium OxideHydrogenLactamsMolecular StructurePiperazinesPiperidinesStereoisomerismUreaAmidesAminesDeuteriumDeuterium OxideHydrogenLactamsPiperazinesPiperidinesUrea

Identifiers

PMID39374416
PMCPMC11527481

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.