ArticleAnnals of clinical and translational neurology2024
Overlap of spike and ripple propagation onset predicts surgical outcome in epilepsy.
Article in Annals of clinical and translational neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Internal and external validation of comprehensive high-frequency activity biomarkers for epilepsy surgery.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2026Article
- [A study on the propagation characteristics of epileptic spike signals based on simultaneous intracranial and scalp electroencephalography].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2026Article
- Epileptogenicity alters intrahippocampal ripple propagation.medRxiv : the preprint server for health sciences · 2026Article
- Predicting surgical outcome in drug-resistant epilepsy by combining interictal biomarkers within a machine learning framework.Scientific reports · 2026Article
- Predicting Surgical Outcome in Drug-Resistant Epilepsy by Combining Interictal Biomarkers within a Machine Learning Framework.Research square · 2026Article
- Internal and External Validation of Comprehensive High-Frequency Activity Biomarkers for Epilepsy Surgery.medRxiv : the preprint server for health sciences · 2025Article
- Not All Spikes Are Equal.Journal of clinical medicine · 2025Review
- Machine learning on interictal intracranial EEG predicts surgical outcome in drug resistant epilepsy.NPJ digital medicine · 2025Article
- Noninvasive classification of physiological and pathological high frequency oscillations in children.Brain communications · 2025Article
- Directionality of neural activity in and out of the seizure onset zone in focal epilepsy.Network neuroscience (Cambridge, Mass.) · 2025Article
- Normative high-frequency oscillation phase-amplitude coupling and effective connectivity under sevoflurane.Brain communications · 2025Article
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Authors and funding
10 authors.
Funding
Abstract
objectiveInterictal biomarkers are critical for identifying the epileptogenic focus. However, spikes and ripples lack specificity while fast ripples lack sensitivity. These biomarkers propagate from more epileptogenic onset to areas of spread. The pathophysiological mechanism of these propagations is elusive. Here, we examine zones where spikes and high frequency oscillations co-occur (SHFO), the spatiotemporal propagations of spikes, ripples, and fast ripples, and evaluate the spike-ripple onset overlap (SRO) as an epilepsy biomarker.
methodsWe retrospectively analyzed intracranial EEG data from 41 patients with drug-resistant epilepsy. We mapped propagations of spikes, ripples, and fast ripples, and identified their onset and spread zones, as well as SHFO and SRO. We then estimated the SRO prognostic value in predicting surgical outcome and compared it to onset and spread zones of spike, ripple, and fast ripple propagations, and SHFO.
resultsWe detected spikes and ripples in all patients and fast ripples in 12 patients (29%). We observed spike and ripple propagations in 40 (98%) patients. Spike and ripple onsets overlapped in 35 (85%) patients. In good outcome patients, SRO showed higher specificity and precision (p < 0.05) in predicting resection compared to onset and zones of spikes, ripples, and SHFO. Only SRO resection predicted outcome (p = 0.01) with positive and negative predictive values of 82% and 57%, respectively.
interpretationSRO is a specific and precise biomarker of the epileptogenic zone whose removal predicts outcome. SRO is present in most patients with drug-resistant epilepsy. Such a biomarker may reduce prolonged intracranial monitoring and improve outcome.
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