Evidence map›Paper›PMID 39374113›Full record

ArticleRNA biology2024

Representation of non-coding RNA-mediated regulation of gene expression using the Gene Ontology.

Giulia Antonazzo, Pascale Gaudet, Ruth C Lovering, Helen Attrill

Abstract read
In one paragraph

Article in RNA biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. The Gene Ontology knowledgebase in 2026.Nucleic acids research · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Giulia AntonazzoDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.ORCID 0000-0003-0086-5621
Pascale GaudetSIB Swiss Institute of Bioinformatics, Swiss-Prot Group, Geneva, Switzerland.ORCID 0000-0003-1813-6857
Ruth C LoveringFunctional Gene Annotation, Institute of Cardiovascular Science, University College London, London, UK.ORCID 0000-0002-9791-0064
Helen AttrillDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.ORCID 0000-0003-3212-6364

Funding

Resource ProjectU41HG002273 · NHGRI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMAS, PAUL D. · 2012 to 2021
$34.7M
Gene Ontology ConsortiumP41HG002273 · NHGRI · JACKSON LABORATORY · PI BLAKE, JUDITH A · 2004 to 2011
$27.4M
Gene Ontology Consortium and KnowledgebaseU24HG012212 · NHGRI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHRISTOPHER J MUNGALL, PAUL Warren STERNBERG · 2022 to 2026
$11.6M
GENE ONTOLOGY CONSORTIUMR01HG002273 · NHGRI · JACKSON LABORATORY · PI BLAKE, JUDITH A · 2001 to 2003
$5.8M
NHGRI NIH HHS P41 HG002273NHGRI NIH HHS R01 HG002273NHGRI NIH HHS U24 HG012212NHGRI NIH HHS U41 HG002273
6 · The paper itself

Abstract

Regulatory non-coding RNAs (ncRNAs) are increasingly recognized as integral to the control of biological processes. This is often through the targeted regulation of mRNA expression, but this is by no means the only mechanism through which regulatory ncRNAs act. The Gene Ontology (GO) has long been used for the systematic annotation of protein-coding and ncRNA gene function, but rapid progress in the understanding of ncRNAs meant that the ontology needed to be revised to accurately reflect current knowledge. Here, a targeted effort to revise GO terms used for the annotation of regulatory ncRNAs is described, focusing on microRNAs (miRNAs), long non-coding RNAs (lncRNAs), small interfering RNAs (siRNAs) and PIWI-interacting RNAs (piRNAs). This paper provides guidance to biocurators annotating ncRNA-mediated processes using the GO and serves as background for researchers wishing to make use of the GO in their studies of ncRNAs and the biological processes they regulate.

Indexed as

Gene Expression RegulationGene OntologyRNA, UntranslatedAnimalsComputational BiologyHumansMicroRNAsMolecular Sequence AnnotationRNA, Long NoncodingRNA, Small InterferingMicroRNAsRNA, Long NoncodingRNA, Small InterferingRNA, UntranslatedbiocurationbioinformaticsGene Ontologygene silencingguidelinesnon-coding RNA

Identifiers

PMID39374113
PMCPMC11459742

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.